走進(jìn)哈獸研
綜合新聞
科研進(jìn)展
科研成果
人才招聘
辦公系統(tǒng)
掃一掃 關(guān)注我
1、個(gè)人簡(jiǎn)介
劉宏揚(yáng)，博士，中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所助理研究員。主要從事以基因敲除小鼠為模型研究宿主天然免疫反應(yīng)的機(jī)制研究。在Cell Reports（2篇）、Journal of Virology（2篇）、Journal of Immunology（1篇）等雜志發(fā)表第一作者科技論文5篇。
2、聯(lián)系方式
電話：1336136126
郵箱：liuhongyang@caas.cn
通訊地址：黑龍江省哈爾濱市香坊區(qū)哈平路678號(hào)
3、教育背景
2019.09-2022.06 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 預(yù)防獸醫(yī)學(xué) 博士
2016.09-2019.06 長(zhǎng)江大學(xué)動(dòng)物科學(xué)技術(shù)學(xué)院 養(yǎng)殖業(yè) 碩士
2012.09-2016.06 山東農(nóng)業(yè)大學(xué)動(dòng)物醫(yī)學(xué)院 動(dòng)物醫(yī)學(xué) 本科
4、工作經(jīng)歷
2022.10至今 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 基礎(chǔ)免疫創(chuàng)新團(tuán)隊(duì) 助理研究員
5、承擔(dān)主要科研項(xiàng)目
1. 國(guó)家自然科學(xué)基金優(yōu)秀青年基金項(xiàng)目：獸醫(yī)免疫學(xué)（32322081，2024.01-2026.12） 200萬(wàn)元，參與；
2. 國(guó)家自然科學(xué)基金專項(xiàng)項(xiàng)目：非洲豬瘟病毒感染與致病機(jī)制（31941002，2019.07-2022.06）300萬(wàn)元，參與。
6、代表性文章
1. Guangqiang Ye, Zhaoxia Zhang, Xiaohong Liu, Hongyang Liu, Weiye Chen, Chunying Feng, Jiangnan Li, Qiongqiong Zhou, Dongming Zhao, Shuai Zhang, Hefeng Chen, Zhigao Bu, Li Huang*, Changjiang Weng*, African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway. Journal of Virology. 2024 Feb 14:e0183423.
2. Guangqiang Ye1, Hongyang Liu1, Xiaohong Liu, Weiye Chen, Jiangnan Li, Dongming Zhao, Gang Wang, Chunying Feng, Zhaoxia Zhang, Qiongqiong Zhou, Jun Zheng, Zhigao Bu, Changjiang Weng, Li Huang, African Swine Fever Virus H240R Protein Inhibits the Production of Type I Interferon through Disrupting the Oligomerization of STING. Journal of Virology. 2023; 97(9): e0057723.
3. Li Huanga, Weiye Chena, Hongyang Liua, Mengdi Xuea, Siqi Dong, Xiaohong Liu, Chunying Feng, Shinuo Cao, Guangqiang Ye, Qiongqiong Zhou, Zhaoxia Zhang, Jun Zheng, Jiangnan Li, Dongming Zhao, Zilong Wang, Encheng Sun, Hefeng Chen, Shuai Zhang, Xue Wang, Xianfeng Zhang, Xijun H, Yuntao Guan, Zhigao Bu*, Changjiang Weng*, African Swine Fever Virus HLJ/18 CD2v Suppresses Type I IFN Production and IFN-Stimulated Genes Expression through Negatively Regulating cGMP-AMP Synthase STING and IFN Signaling Pathways. Journal of Immunology. 2023, 210 (9): 1338-1350.
4. Qiongqiong Zhoua, Longfeng Zhanga, Qihong Lin, Hongyang Liu, Guangqiang Ye, Xiaohong Liu, Shuang Jiao, Jiangnan Li, Yandong Tang, Deshi Shi, Li huang*, Changjiang Weng*, Mechanism of PRV infection activating TLRs-NF-kB axis and AIM2 inflammasome to enhance inflammatory response. Journal of Virology. 2023, 97 (3).
5. Li Huang1, Hongyang Liu1, Guangqiang Ye1, Xiaohong Liu, Weiye Chen, Zilong Wang, Shijun Zhou, Dongming Zhao, Zhaoxia Zhang, Chunying Feng, Xianfeng Zhang, Xijun He, Jun Zheng, Zhigao Bu*, Jiangnan Li*, Changjiang Weng*, ASFV pH240R affects the virulence of African swine fever virus by inhibiting type I interferon signaling and NLRP3-mediated inflammatory responses. Journal of Virology. 2023, 97 (2).
6. Hongyang Liu1, Guangqiang Ye1, Xiaohong Liu, Mengdi Xue, Qiongqiong Zhou, Longfeng Zhang, Kunli Zhang, Li Huang*, Changjiang Weng*. Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis. Cell Reports. 2022, 41, 111469.
7. Xiaohong Liu, Hongyang Liu, Guangqiang Ye, Mengdi Xue, Huibin Yu, Chunying Feng, Qiongqiong Zhou, Xuemin Liu, Longfeng Zhang, Shuang Jiao, Changjiang Weng*, Li Huang*. African swine fever virus pE301R negatively regulates cGAS-STING signaling pathway by inhibiting the nuclear translocation of IRF3. Veterinary Microbiology. 274 (2022) 109556.
8. Qiongqiong Zhou, Longfeng Zhang, Hongyang Liu, Guangqian Ye, Li Huang*, Changjiang Weng*. Isolation and Characterization of Two Pseudorabies Virus and Evaluation of Their Effects on Host Natural Immune Responses and Pathogenicity. Viruses, 2022 14 (4): 712.
9. Li Huang1, Wenjie Xu1, Hongyang Liu, Mengdi Xue, Xiaohong Liu, Kunli Zhang, Liang Hu, Jiangnan Li, Xuemin Liu, Zhida Xiang, Jun Zheng, Changyao Li, Weiye Chen, Zhigao Bu, Tao Xiong*, and Changjiang Weng*, African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 toInhibit K63-Linked Ubiquitination of TBK1. Journal of Immunology, 2021 207(11): 2754-2769.
10. Li Huang#, Hongyang Liu#, Kunli Zhang, Qingwen Meng, Liang Hu, Yuanfeng Zhang, Zhida Xiang, Jiangnan Li, Yuying Yang, Yali Chen, Shangjin Cui, Hong Tang, Huadong Pei, Zhigao Bu, and Changjiang Weng, Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1. Cell Reports. 2020, 32, 108044.
11. Kunli Zhang, Yuanfeng Zhang, Juan Xue, Qingwen Meng, Hongyang Liu, Caihong Bi, Changyao Li, Liang Hu, Huibin Yu, Tao Xiong, Yuying Yang, Shangjin Cui, Zhigao Bu, Xijun He, Jiangnan Li, Li Huang*, Changjiang Weng*. DDX19 inhibits type I interferon production by disrupting TBK1-IKKε-IRF3 interactions and promoting TBK1 and IKKε degradation. Cell Reports. 2019 26: 1258-1272.
掃一掃 關(guān)注我
網(wǎng)站首頁(yè)
聯(lián)系我們