1、個人簡歷
翁長江，博士，研究員，博士生導師，中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所基礎(chǔ)免疫創(chuàng)新團隊首席科學家，中國農(nóng)業(yè)科學院領(lǐng)軍人才，黑龍江省獸醫(yī)免疫學重點實驗室主任。主要從事非洲豬瘟病毒(ASFV)、豬繁殖與呼吸綜合征病毒(PRRSV)等感染、免疫逃逸和致病機制的研究。近年來，主持國家自然科學基金委非洲豬瘟重點專項、地區(qū)聯(lián)合創(chuàng)新基金、面上項目、中國農(nóng)業(yè)科學院知識創(chuàng)新工程和科技部“十四五”重點研發(fā)計劃項目。近五年在Cell Rep、PLoS Pathog、J Biol Chem、J Immunol等雜志發(fā)表科技論文50余篇，被國內(nèi)外同行引用500余次。中國細胞生物學學會免疫細胞學分會理事、中國免疫學會獸醫(yī)免疫學分會理事和全國農(nóng)業(yè)生物化學與分子生物學學會理事。先后擔任昆明理工大學、長江大學、浙江農(nóng)林科技大學、沈陽農(nóng)業(yè)大學和吉林農(nóng)業(yè)大學客座教授。獲得中華農(nóng)業(yè)科技獎1項。
2、聯(lián)系方式
電話：0451-51051756
郵件：wengchangjiang@caas.cn; wengchji@163.com
通訊地址：黑龍江省哈爾濱市香坊區(qū)哈平路678號 150069
3、教育背景
2000.09-2005.10 中國科學院/中國科學院研究生院 微生物研究所 博士
1996.09-1999.07 華中農(nóng)業(yè)大學 動物醫(yī)學院 碩士
1991.09-1994.07 湖北農(nóng)學院 畜牧獸醫(yī)專業(yè)（長江大學 動物醫(yī)學系）
4、工作經(jīng)歷
2016.07-今 哈爾濱獸醫(yī)研究所基礎(chǔ)免疫團隊首席科學家
2010.10-2016.06 哈爾濱獸醫(yī)研究所 豬繁殖與呼吸綜合征基礎(chǔ)研究組負責人
2008.10-2010.10 美國加州大學舊金山分校 博士后
2005.10-2008.10 美國Stowers Institute 博士后
1994.07-1996.09 黃石市農(nóng)業(yè)局
5、承擔主要科研項目
1. 國家自然科學基金委地區(qū)聯(lián)合創(chuàng)新基金，非洲豬瘟病毒免疫調(diào)節(jié)基因的功能及其在病毒感染致病中的作用（260萬），2022.1-2025.12，在研，主持。
2. 國家自然科學基金委非洲豬瘟基礎(chǔ)研究重點專項，非洲豬瘟感染及致病機制研究（300萬），批準號31941002，2019.7-2022.12，在研，主持。
3. 國家自然科學基金委面上基金，免疫球蛋白lambda鏈及其相似肽抑制I型干擾素產(chǎn)生的分子機制及促進PRRSV復制的研究（15萬），批準號31640083，2017.1-2017.12，在研，結(jié)題。
4. 中國農(nóng)業(yè)科學院創(chuàng)新工程基金，豬繁殖與呼吸綜合征病毒-細菌混合感染基礎(chǔ)研究（60萬），2016.1-2016.12，結(jié)題，主持。
5. 中國農(nóng)業(yè)科學院創(chuàng)新工程基金，豬繁殖與呼吸綜合征病毒基礎(chǔ)研究（128萬），2013.1-2015.12，結(jié)題，主持。
6. 國家自然科學基金青年基金，PRRSV NSP1β與HSP40 互作抑制I 型干擾素的產(chǎn)生分子機制（25萬），批準號31302163，2014.1-2016.12，結(jié)題，參與。
7. 中國農(nóng)業(yè)科學院青年基金配套基金，病毒RNA 感受蛋白DDX19A 功能的研究（10萬），批準號302014024，2014.1-2014.12，結(jié)題，主持。
8. 中國農(nóng)業(yè)科學院增量項目，重要動物病毒在巨噬細胞中復制及調(diào)控天然免疫機制的研究（87萬），批準號2013ZL034，2013.1-2015.12，結(jié)題，主持。
9. 重點實驗室課題，宿主蛋白參與PRRSV 復制機理的研究(15萬))，批準號SKLVBP201309，2013.1-2013.12，結(jié)題，主持。
10. 國家自然科學基金面上項目，PRRSV 編碼蛋白與宿主蛋白相互作用的研究(57萬)，批準號31172333，2012.1-2015.12,結(jié)題，主持。
11. 重點實驗室課題，PRRSV 非結(jié)構(gòu)蛋白NSP1β 抑制天然免疫的分子基礎(chǔ)(30萬)，批準號SKLVBP2012, 2012.1-2012.12，結(jié)題，主持。
12. 重點實驗室課題，PRRSV 編碼蛋白與宿主蛋白相互作用網(wǎng)絡的構(gòu)建(50萬），批準號SKLVBP201026，2011.1-2011.12，結(jié)題，主持。
6、代表性文章
1. Guangqiang Ye, Zhaoxia Zhang, Xiaohong Liu, Hongyang Liu, Weiye Chen, Chunying Feng, Jiangnan Li, Qiongqiong Zhou, Dongming Zhao, Shuai Zhang, Hefeng Chen, Zhigao Bu, Li Huang*, Changjiang Weng*, African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway. Journal of Virology. 2024 Feb 14:e0183423.
2. Tingting Li*, Jun Zheng*, Tao Huang, Xiao Wang, Jiangnan Li, Feng Jin, Wenjuan Wei, Xin Chen, Chuanxia Liu, Miaofei Bao, Gaihong Zhao, Li Huang, Dongming Zhao, Jianxin Chen, Zhigao Bu, Changjiang Weng*. African swine fever virus replication inhibitors by screening of a library of FDA-approved drugs. Virology. 2024 Feb 14;593:110014.
3. Guangqiang Ye, Hongyang Liu, Xiaohong Liu, Weiye Chen, Jiangnan Li, Dongming Zhao, Gang Wang, Chunying Feng, Zhaoxia Zhang, Qiongqiong Zhou, Jun Zheng, Zhigao Bu, Changjiang Weng*, Li Huang, African Swine Fever Virus H240R Protein Inhibits the Production of Type I Interferon through Disrupting the Oligomerization of STING. Journal of Virology. 2023; 97(9): e0057723.
4. Li Huanga, Weiye Chena, Hongyang Liua, Mengdi Xuea, Siqi Dong, Xiaohong Liu, Chunying Feng, Shinuo Cao, Guangqiang Ye, Qiongqiong Zhou, Zhaoxia Zhang, Jun Zheng, Jiangnan Li, Dongming Zhao, Zilong Wang, Encheng Sun, Hefeng Chen, Shuai Zhang, Xue Wang, Xianfeng Zhang, Xijun H, Yuntao Guan, Zhigao Bu*, Changjiang Weng*, African Swine Fever Virus HLJ/18 CD2v Suppresses Type I IFN Production and IFN-Stimulated Genes Expression through Negatively Regulating cGMP-AMP Synthase STING and IFN Signaling Pathways. Journal of Immunology. 2023, 210 (9): 1338-1350.
5. Qiongqiong Zhoua, Longfeng Zhanga, Qihong Lin, Hongyang Liu, Guangqiang Ye, Xiaohong Liu, Shuang Jiao, Jiangnan Li, Yandong Tang, Deshi Shi, Li Huang*, Changjiang Weng*, Mechanism of PRV infection activating TLRs-NF-kB axis and AIM2 inflammasome to enhance inflammatory response. Journal of Virology. 2023, 97 (3).
6. Li Huang, Hongyang Liu, Guangqiang Ye, Xiaohong Liu, Weiye Chen, Zilong Wang, Shijun Zhou, Dongming Zhao, Zhaoxia Zhang, Chunying Feng, Xianfeng Zhang, Xijun He, Jun Zheng, Zhigao Bu*, Jiangnan Li*, Changjiang Weng*, ASFV pH240R affects the virulence of African swine fever virus by inhibiting type I interferon signaling and NLRP3-mediated inflammatory responses. Journal of Virology. 2023, 97 (2).
7. Tingting Li*, Xuewen Li*, Xiao Wang, Xin Chen, Gaihong Zhao, Chuanxia Liu, Miaofei Bao, Jie Song, Jiangnan Li, Li Huang, Jun Rong, Kegong Tian, Junhua Deng, Jianzhong Zhu, Xuehui Cai, Zhigao Bu, Jun Zheng, Changjiang Weng*. African swine fever virus pS273R antagonizes stress granule formation by cleaving the nucleating protein G3BP1 to facilitate viral replication. Journal of Biological chemistry, 2023 Jul;299(7):104844.
8. Xin Chen, Jun Zheng, Chuanxia Liu, Tingting Li, Xiao Wang, Xuewen Li, Miaofei Bao, Jiangnan Li, Li Huang, Zhaoxia Zhang, Zhigao Bu, Changjiang Weng*. CD1d facilitates African swine fever virus entry into the host cells via clathrin-mediated endocytosis. Emerg Microbes Infect. 2023 Dec;12(2):2220575.
9. Xin Chen, Jun Zheng, Tingting Li, Chuanxia Liu, Miaofei Bao, Xiao Wang, Xuewen Li, Jiangnan Li, Li Huang, Zhaoxia Zhang, Changjiang Weng*. Coreceptor AXL Facilitates African Swine Fever Virus Entry via Apoptotic Mimicry. Journal of Virology. 2023 Jul 27;97(7):e0061623.
10. Jiangnan Li, Jie Song, Shijun Zhou, Shuai Li, Jia Liu, Tingting Li, Zhaoxia Zhang, Xianfeng Zhang, Xijun He, Weiye Chen, Jun Zheng, Dongming Zhao, Zhigao Bu, Li Huang, Changjiang Weng*. Development of a new effective African swine fever virus vaccine candidate by deletion of the H240R and MGF505-7R genes results in protective immunity against the Eurasia strain. Journal of Virology. 2023 Oct 31;97(10):e0070423.
11. Hongyang Liu1, Guangqiang Ye1, Xiaohong Liu, Mengdi Xue, Qiongqiong Zhou, Longfeng Zhang, Kunli Zhang, Li Huang*, Changjiang Weng*. Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis. Cell Reports. 2022, 41, 111469.
12. Xiaohong Liu, Hongyang Liu, Guangqiang Ye, Mengdi Xue, Huibin Yu, Chunying Feng, Qiongqiong Zhou, Xuemin Liu, Longfeng Zhang, Shuang Jiao, Changjiang Weng*, Li Huang*. African swine fever virus pE301R negatively regulates cGAS-STING signaling pathway by inhibiting the nuclear translocation of IRF3. Veterinary Microbiology. 274 (2022) 109556.
13. Qiongqiong Zhou, Longfeng Zhang, Hongyang Liu, Guangqian Ye, Li Huang*, Changjiang Weng*. Isolation and Characterization of Two Pseudorabies Virus and Evaluation of Their Effects on Host Natural Immune Responses and Pathogenicity. Viruses, 2022 14 (4): 712.
14. Li Huang, Jiangnan Li, Jun Zheng, Dan Li, Changjiang Weng*. Multifunctional pMGF505-7R is a key virulence-related factor of African Swine Fever Virus. Frontiers in Microbiology, 2022. 852431.
15. Tingting Li#, Gaihong Zhao#, Taoqin Zhang, Zhaoxia Zhang, Xin Chen, Jie Song, Xiao Wang, Jiangnan Li, Li Huang, Lili Wen, Changyao Li, Dongming Zhao, Xijun He, Zhigao Bu, Jun Zheng*, Changjiang Weng*. African Swine Fever Virus pE199L Induces Mitochondrial-Dependent Apoptosis. Viruses. 2021 Nov 8;13(11):2240.
16. Li Huang#, Wenjie Xu#, Hongyang Liu, Mengdi Xue, Xueming Liu, Kunli Zhang, Liang Hu, Jiangnan Li, Zhida Xiang, Jun Zheng, Changyao Li, Weiye Chen, Zhigao Bu,, Tiao Xiong, Changjiang Weng*. African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1. J Immunol. 2021 Dec 1;207(11):2754-2769.
17. Jiangnan Li#, Jie Song#, Li Kang, Li Huang, Zhijun Zhou, Liang Hu, Jun Zheng, Changyao Li, Zhang X, Xijun He, Dongming Zhao, Zhigao Bu*, Changjiang Weng*. pMGF505-7R determines pathogenicity of African swine fever virus infection by inhibiting IL-1β and type I IFN production. PLoS Pathog. 2021 Jul 26;17(7):e1009733.
19. Li Hu, Xingbo Cheng, Zev Binder, Zhibin Han,Yibo Yin, Donald M O'Rourke, Sida Wang,Yumeng Feng, Changjiang Weng, Anhua Wu, Zhiguo Lin. Molecular and Clinical Characterization of UBE2S in Glioma as a Biomarker for Poor Prognosis and Resistance to Chemo-Radiotherapy. Front Oncol. 2021 May 27;11:640910.
20. Li Du, Honglei Wang, Fang Liu, Zeyu Wei, Changjiang Weng, Jun Tang, Wen-Hai Feng. NSP2 Is Important for Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus to Trigger High Fever-Related COX-2-PGE2 Pathway in Pigs. Front Immunol. 2021 Apr 29;12:657071.
21. Jie Song, Kang Li, Ting Li, Gaihong Zhao, Shijun Zhou, Huang Li, Jiangnan Li, Changjiang Weng*. Screening of PRRSV- and ASFV-encoded proteins involved in the inflammatory response using a porcine iGLuc reporter. J Virol Methods. 2020 Nov;285:113958.
22. Li Huang,# Hongyang Liu, Kunli Zhang, Qingwen Meng, Liang Hu, Yuanfeng Zhang, Zhida Xiang, Jiangnan Li, Yuying Yang, Yali Chen, Shangjin Cui, Hong Tang, Huadong Pei, Zhigao Bu, Changjiang Weng*. Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1. Cell Rep. 2020 Aug 18;32(7):108044.
23. Chao Sun, Mengmeng Liu, Jitao Chang, Decheng Yang, Bo Zhao, Haiwei Wang, Guohui Zhou, Changjiang Weng, Li Yu*. Heterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5' Untranslated Region. J Virol. 2020 May 4; 94(10): e00282-20.
24. Zhaoxia Zhang, Haorong Gu, Qi Li, Jun Zheng, Shinuo Cao, Changjiang Weng, Honglin Jia. GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon. Infect Immun. 2020 Apr 20; 88(5): e00054-20.
25. Xiaoying Zhi, Yun Zhang, Shiqi Sun, Zhihui Zhang, Hu Dong, Xin Luo, Yanquan Wei, Zengjun Lu, Yongxi Dou, Run Wu, Zhengfan Jiang, Changjiang Weng, Ho Seong Seo, Huichen Guo. NLRP3 inflammasome activation by Foot-and-mouth disease virus infection mainly induced by viral RNA and non-structural protein 2B. RNA Biol. 2020 Mar;17(3):335-349.
26. Kunli Zhang#, Yuanfeng Zhang#, Juan Xue, Qingwen Meng, Hongyang Liu, Caihong Bi, Changyao Li, Liang Hu, Huibin Yu, Tao Xiong, Yuying Yang, Shangjin Cui, Zhigao Bu, Xijun He, Jiangnan Li, Li Huang, Changjiang Weng*. DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation. Cell Rep. 2019 29;26(5):1258-1272.
27. Changyao Li, Yan Chai, Hao Song, Changjiang Weng, Jianxun Qi, Yeping Sun, George F Gao. Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target. MBio. 2019 Oct 29;10(5).
7、申請專利
1. 翁長江、蔡雪輝、李江南、王承寶、劉永剛、黃麗、石文達. 豬繁殖與呼吸綜合征病毒疫苗株CH1a cDNA感染性克隆及其應用 專利申請?zhí)枺?01310682463.6
2. 翁長江、崔尚金、黃麗、李江南.一種豬腦心肌炎病毒HB10株感染性克隆的構(gòu)建及應用 專利申請?zhí)枺?01410330789.7
3. 基于非洲豬瘟p54蛋白建立ELISA抗體檢測試劑盒及應用
4. 基于非洲豬瘟p30蛋白建立ELISA抗體檢測試劑盒及應用
走進哈獸研
綜合新聞
科研進展
科研成果
人才招聘
辦公系統(tǒng)
網(wǎng)站首頁
聯(lián)系我們