走進(jìn)哈獸研
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1、個(gè)人簡(jiǎn)介
黃麗，研究員，博士生導(dǎo)師，國(guó)家自然科學(xué)基金優(yōu)秀青年基金獲得者，中國(guó)農(nóng)業(yè)科學(xué)院杰出青年英才。任農(nóng)業(yè)農(nóng)村部經(jīng)濟(jì)動(dòng)物疫病重點(diǎn)實(shí)驗(yàn)室學(xué)術(shù)委員、中國(guó)生物化學(xué)與分子生物學(xué)會(huì)農(nóng)業(yè)生物化學(xué)與分子生物學(xué)分會(huì)委員兼副秘書長(zhǎng)、中國(guó)免疫學(xué)會(huì)獸醫(yī)免疫學(xué)分會(huì)理事、中國(guó)畜牧獸醫(yī)學(xué)會(huì)獸醫(yī)傳染病學(xué)分會(huì)青年委員、中國(guó)免疫學(xué)會(huì)黑龍江省免疫學(xué)分會(huì)理事、黑龍江省蛋白質(zhì)組學(xué)學(xué)會(huì)理事、黑龍江省青年科技工作者協(xié)會(huì)會(huì)員、黑龍江省獸醫(yī)免疫學(xué)重點(diǎn)實(shí)驗(yàn)室學(xué)術(shù)帶頭人、Frontiers in Immunology、Microorganisms、Animals等期刊客座主編、mLife期刊和中國(guó)農(nóng)業(yè)科學(xué)雜志青年編委、Animal Diseases雜志科學(xué)編輯、Cell、Journal of Virology等雜志審稿人；2023年獲得“哈爾濱市三八紅旗手”榮譽(yù)稱號(hào)；2024年當(dāng)選黑龍江省婦女第十三次代表大會(huì)代表；主要從事非洲豬瘟病毒、豬偽狂犬病病毒等重要?jiǎng)游锊《咎右菟拗魈烊幻庖邫C(jī)制研究；主持國(guó)家自然科學(xué)基金優(yōu)青項(xiàng)目等國(guó)家級(jí)項(xiàng)目5項(xiàng)；在Cell Reports（3篇）、Autophagy、PLoS Pathogens (2篇)、Journal of Virology（5篇）、Journal of Immunology（2篇）等雜志發(fā)表第一作者或者通訊作者（含共同）科技論文20余篇；研發(fā)非洲豬瘟病毒ELISA抗體檢測(cè)試劑盒2個(gè)，成果轉(zhuǎn)化400萬(wàn)元；獲得國(guó)家發(fā)明專利3項(xiàng)、中華農(nóng)業(yè)科技獎(jiǎng)1項(xiàng)、中國(guó)農(nóng)業(yè)科學(xué)院科技成果獎(jiǎng)1項(xiàng)。
2、聯(lián)系方式
電話：0451-51051759
郵箱：highlight0315@163.com
通訊地址：黑龍江省哈爾濱市香坊區(qū)哈平路678號(hào)
3、教育背景
2007/09-2012/06 南京農(nóng)業(yè)大學(xué)動(dòng)物醫(yī)學(xué)院 預(yù)防獸醫(yī)學(xué) 博士
2005/09-2007/09 山東農(nóng)業(yè)大學(xué)動(dòng)物醫(yī)學(xué)院 預(yù)防獸醫(yī)學(xué) 本科
4、工作經(jīng)歷
2012.07-2016.12 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 助理研究員
2017.01-2021.12 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 基礎(chǔ)免疫創(chuàng)新團(tuán)隊(duì) 副研究員
2022.01至今，中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所，基礎(chǔ)免疫創(chuàng)新團(tuán)隊(duì) 研究員
5、承擔(dān)主要科研項(xiàng)目
1.國(guó)家自然科學(xué)基金優(yōu)秀青年基金項(xiàng)目：獸醫(yī)免疫學(xué)，（32322081，2024.01-2026.12） 200萬(wàn)元，主持；
2.中國(guó)農(nóng)業(yè)科學(xué)院科學(xué)中心項(xiàng)目：禽流感和非洲豬瘟等畜禽重要疫病病原與宿主互作機(jī)制研究，（CAAS-CSLPDCP-202401，2024.01-2028.01），100萬(wàn)元，主持；
3.國(guó)家自然科學(xué)基金面上項(xiàng)目：波形蛋白識(shí)別非洲豬瘟病毒DNA激活NLRP3炎癥小體的分子機(jī)制，（32270156，2023.01-2026.12）54萬(wàn)元，主持；
4.國(guó)家重點(diǎn)研發(fā)計(jì)劃“非洲豬瘟亞單位疫苗創(chuàng)制”重點(diǎn)專項(xiàng)子課題：ASF亞單位疫苗的TCR和BCR免疫組庫(kù)模型建立與驗(yàn)證（2021YFD1801300，2021.12-2024.11），100萬(wàn)元，主持；
5.黑龍江省自然科學(xué)基金優(yōu)秀青年項(xiàng)目：非洲豬瘟病毒pI215L蛋白抑制I型干擾素產(chǎn)生的分子機(jī)制，（YQ2020C022，2020.07-2023.07），10萬(wàn)元，主持；
6.國(guó)家重點(diǎn)研發(fā)計(jì)劃子課題：生物安全關(guān)鍵技術(shù)研發(fā)重點(diǎn)專項(xiàng)2018年度項(xiàng)目，（2018YFC1200902, 2018.06-2021.06），50萬(wàn)元，主持；
7.國(guó)家自然科學(xué)基金專項(xiàng)項(xiàng)目：非洲豬瘟病毒感染與致病機(jī)制，（31941002，2019.07-2022.06），300萬(wàn)元，參與；
8.國(guó)家自然科學(xué)基金青年基金：20S蛋白酶體亞基在腦心肌炎病毒復(fù)制與組裝中的作用，（31300139，2014.01-2016.12），23萬(wàn)元，主持。
6、代表性文章
1. Qiongqiong Zhou, Deshi Shi, Yan-Dong Tang, Longfeng Zhang, Hongyang Liu, Guangqiang Ye, Zhaoxia Zhang, Boli Hu, Li Huang*, Changjiang Weng*, Pseudorabies virus gM protein and herpesvirus homologs block selective autophagy to enhance viral replication. Autophagy. 2025; 2511584.
2. Qiongqiong Zhou, Deshi Shi, Yan-Dong Tang, Longfeng Zhang, Boli Hu, Chunfu Zheng, Li Huang*, Changjiang Weng*, Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity. PLoS Pathogens. 2024; 20(4):e1012146.
3. Xiaohong Liu, Hefeng Chen, Guangqiang Ye, Hongyang Liu, Chunying Feng, Weiye Chen, Liang Hu, Qiongqiong Zhou, Zhaoxia Zhang, Jiangnan Li, Xianfeng Zhang, Xijun He, Yuntao Guan, Zhengshuang Wu, Dongming Zhao, Zhigao Bu*, Changjiang Weng*, Li Huang*, African swine fever virus pB318L, a trans-geranylgeranyl-diphosphate synthase, negatively regulates cGAS-STING and IFNAR-JAK-STAT signaling pathways. PLoS Pathogens. 2024; 20(4):e1012136.
4. Guangqiang Ye, Zhaoxia Zhang, Xiaohong Liu, Hongyang Liu, Weiye Chen, Chunying Feng, Jiangnan Li, Qiongqiong Zhou, Dongming Zhao, Shuai Zhang, Hefeng Chen, Zhigao Bu, Li Huang*, Changjiang Weng*, African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway. Journal of Virology. 2024; 98(3):e0183423.
5. Jiangnan Li , Jie Song, Shijun Zhou, Shuai Li, Jia Liu , Tingting Li, Zhaoxia Zhang, Xianfeng Zhang, Xijun He, Weiye Chen, Jun Zheng, Dongming Zhao, Zhigao Bu, Li Huang*, Changjiang Weng*, Development of a new effective African swine fever virus vaccine candidate by deletion of the H240R and MGF505-7R genes results in protective immunity against the Eurasia strain. Journal of Virology. 2023 97(10):e0070423.
6. Guangqiang Ye, Hongyang Liu, Xiaohong Liu, Weiye Chen, Jiangnan Li, Dongming Zhao, Gang Wang, Chunying Feng, Zhaoxia Zhang, Qiongqiong Zhou, Jun Zheng, Zhigao Bu, Changjiang Weng, Li Huang, African Swine Fever Virus H240R Protein Inhibits the Production of Type I Interferon through Disrupting the Oligomerization of STING. Journal of Virology. 2023; 97(9): e0057723.
7. Li Huang a, Weiye Chena, Hongyang Liua, Mengdi Xuea, Siqi Dong, Xiaohong Liu, Chunying Feng, Shinuo Cao, Guangqiang Ye, Qiongqiong Zhou, Zhaoxia Zhang, Jun Zheng, Jiangnan Li, Dongming Zhao, Zilong Wang, Encheng Sun, Hefeng Chen, Shuai Zhang, Xue Wang, Xianfeng Zhang, Xijun H, Yuntao Guan, Zhigao Bu*, Changjiang Weng*, African Swine Fever Virus HLJ/18 CD2v Suppresses Type I IFN Production and IFN-Stimulated Genes Expression through Negatively Regulating cGMP-AMP Synthase STING and IFN Signaling Pathways. Journal of Immunology. 2023, 210 (9): 1338-1350.
8. Qiongqiong Zhoua, Longfeng Zhanga, Qihong Lin, Hongyang Liu, Guangqiang Ye, Xiaohong Liu, Shuang Jiao, Jiangnan Li, Yandong Tang, Deshi Shi, Li Huang*, Changjiang Weng*, Pseudorabies Virus Infection Activates the TLR-NF-κB Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice. Journal of Virology. 2023, 97 (3):e0000323.
9. Li Huang, Hongyang Liu, Guangqiang Ye, Xiaohong Liu, Weiye Chen, Zilong Wang, Shijun Zhou, Dongming Zhao, Zhaoxia Zhang, Chunying Feng, Xianfeng Zhang, Xijun He, Jun Zheng, Zhigao Bu*, Jiangnan Li*, Changjiang Weng*, Deletion of African Swine Fever Virus (ASFV) H240R Gene Attenuates the Virulence of ASFV by Enhancing NLRP3-Mediated Inflammatory Responses. Journal of Virology. 2023, 97 (2):e0122722.
10. Hongyang Liu1, Guangqiang Ye1, Xiaohong Liu, Mengdi Xue, Qiongqiong Zhou, Longfeng Zhang, Kunli Zhang, Li Huang*, Changjiang Weng*. Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis. Cell Reports. 2022, 41, 111469.
11. Xiaohong Liu, Hongyang Liu, Guangqiang Ye, Mengdi Xue, Huibin Yu, Chunying Feng, Qiongqiong Zhou, Xuemin Liu, Longfeng Zhang, Shuang Jiao, Changjiang Weng*, Li Huang*. African swine fever virus pE301R negatively regulates cGAS-STING signaling pathway by inhibiting the nuclear translocation of IRF3. Veterinary Microbiology. 274 (2022) 109556.
12. Qiongqiong Zhou, Longfeng Zhang, Hongyang Liu, Guangqian Ye, Li Huang*, Changjiang Weng*. Isolation and Characterization of Two Pseudorabies Virus and Evaluation of Their Effects on Host Natural Immune Responses and Pathogenicity. Viruses, 2022 14 (4): 712.
13. Li Huang, Jiangnan Li, Jun Zheng, Dan Li, Changjiang Weng, Multifunctional pMGF505-7R is a key virulence-related factor of African Swine Fever Virus. Frontiers in Microbiology, 2022. 852431.
14. Li Huang1, Wenjie Xu1, Hongyang Liu, Mengdi Xue, Xiaohong Liu, Kunli Zhang, Liang Hu, Jiangnan Li, Xuemin Liu, Zhida Xiang, Jun Zheng, Changyao Li, Weiye Chen, Zhigao Bu, Tao Xiong*, and Changjiang Weng*, African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1. Journal of Immunology, 2021 207(11): 2754-2769.
15. Li Huang#, Hongyang Liu#, Kunli Zhang, Qingwen Meng, Liang Hu, Yuanfeng Zhang, Zhida Xiang, Jiangnan Li, Yuying Yang, Yali Chen, Shangjin Cui, Hong Tang, Huadong Pei, Zhigao Bu, and Changjiang Weng, Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1. Cell Reports. 2020, 32, 108044.
16. Kunli Zhang, Yuanfeng Zhang, Juan Xue, Qingwen Meng, Hongyang Liu, Caihong Bi, Changyao Li, Liang Hu, Huibin Yu, Tao Xiong, Yuying Yang, Shangjin Cui, Zhigao Bu, Xijun He, Jiangnan Li, Li Huang*, Changjiang Weng*. DDX19 inhibits type I interferon production by disrupting TBK1-IKKε-IRF3 interactions and promoting TBK1 and IKKε degradation. Cell Reports. 2019 26: 1258-1272.
17. Li Huang, Tao Xiong, Huibin Yu, Quan Zhang, Kunli Zhang, Changyao Li, Liang Hu, Yuanfeng Zhang, Lijie Zhang, Qinfang Liu, Shengnan Wang, Xijun He, Zhigao Bu, Xuehui Cai, Shangjin Cui, Jiangnan Li and Changjiang Weng*. Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK-TBK1-IKKε-IRF3 complex. Biochemical Journal. 2017 474: 2051-2065.
18. Jiangnan Li, Shengnan Wang, Li Huang*, Changjiang Weng*. Secondary Haemophilus parasuis infection enhances highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection-mediated inflammatory responses. Veterinary Microbiology. 2017, 204: 35-42.
19. Huibin Yu1, Li Huang1, Yuanfeng Zhang, Liang Hu, Shengnan Wang, Jiangnan Li, Xuehui Cai, Shangjin Cui, Changjiang Weng. An attenuated EMCV-HB10 strain acts as a live viral vector delivering a foreign gene. Journal of General Virology. 2016; 97(9):2280-90.
20. Li Huang, Qinfang Liu, Lijie Zhang, Quan Zhang, Liang Hu, Changyao Li, Shengnan Wang, Jiangnan Li, Yuanfeng Zhang, Huibin Yu, Yan Wang, Zhaohua Zhong, Tao Xiong, Xueshan Xia, Xiaojun Wang, Li Yu, Guohua Deng, Xuehui Cai, Shangjin Cui, Changjiang Weng*. Encephalomyocarditis Virus 3C Protease relieves TANK Inhibitory Effect on TRAF6-mediated NF-kappaB Signaling through Cleavage of TANK, Journal of Biological Chemistry, 2015, 290(46): 27618-32.
21. Li Huang, Ruibing Cao, Ning Wang, Ke Liu, Jianchao Wei, Hassan Isahga, Lijie Song Weiyong Zuo, Bin Zhou, Weiwu Wang, Xiang Mao*, Puyan Chen*. The design and Recombinant Protein expression of a Consensus Porcine Interferon: CoPoIFN-α, Cytokine, 2012, 57(1): 37-45.
22. Li Huang, Xiang Mao*, Najmoutin G. Abdulaev, Tony Ngo, Wei Liu, and Kevin D. Ridge. One-step Purification of a Functional, Constitutively Activated Form of Visual Arrestin, Protein expression and purification, 2012, 82(1): 55-60.
23. Ming-xia Sun, Li Huang, Rui Wang, Ya-ling Yu, Chen Li, Peng-peng Li, Xiao-chun Hu, Hong-ping Hao, Hassan. A. shag, Xiang Mao. Porcine Reproductive and Respiratory syndrome Virus Induce Autophagy to Promote Virus Replication. Autophagy. 2012, 8:1434-1447.
24. Li Huang, Yuanpeng Zhang, Yaling Yu, Mingxia Sun, Chen Li, Bo Ni, Xiuhua Wang, Puyan Chen, Xiang Mao*. Role of cholesterol in porcine reproductive and respiratory syndrome virus (PRRSV) infection on MARC-145 cells. Biochemical and Biophysical Research Communications. 2011, 414(3): 545-50.
7、專利
1. 黃麗，陳溥言，侯鳳香，劉珂，曹瑞兵。一種復(fù)合豬α干擾素基因及其重組載體，ZL201010125057.6，發(fā)明專利，中國(guó).
2. 步志高，翁長(zhǎng)江，李江南，黃麗，陳偉業(yè)，趙東明，鄭君，張朝霞，一種非洲豬瘟病毒基因缺失的重組減毒株及其制備方法與應(yīng)用，ZL202211365536.4，發(fā)明專利，中國(guó).
8. 產(chǎn)品轉(zhuǎn)化
1. 非洲豬瘟病毒ELISA抗體檢測(cè)試劑盒（p30），技術(shù)轉(zhuǎn)讓，廣州悅洋生物技術(shù)有限公司
2. 非洲豬瘟病毒ELISA抗體檢測(cè)試劑盒，技術(shù)轉(zhuǎn)讓，鄭州中道生物技術(shù)有限公司
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