1、個人簡介
趙東明，博士，中共黨員，中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所研究員，博士生導師，非洲豬瘟防控創(chuàng)新團隊首席科學家，重要人獸共患病創(chuàng)新團隊黨支部書記，中組部國家級青年人才，中國農(nóng)業(yè)科學院“農(nóng)科英才”領(lǐng)軍人才B類，黑龍江省“頭雁行動計劃”獸醫(yī)病毒學創(chuàng)新研究團隊骨干。自非洲豬瘟傳入我國以來，一直致力于非洲豬瘟基礎(chǔ)與防控研究，首次分離出我國非洲豬瘟強毒及基因II和I型低致死毒株，分別完成其基因組進化和致病性研究；解析了病毒顆粒精細結(jié)構(gòu)并提出組裝機制假說；作為核心骨干，創(chuàng)制出安全有效的非洲豬瘟弱毒疫苗，突破疫苗產(chǎn)業(yè)化瓶頸，完成農(nóng)業(yè)轉(zhuǎn)基因生物安全評價及臨床試驗；研制出非洲豬瘟抗體檢測試劑盒，通過應(yīng)急評價獲生產(chǎn)許可，為我國非洲豬瘟防控提供理論及技術(shù)支撐。以第一或通訊作者（含共同）在Science、PLOS Pathogens、Protein and Cell、Journal of Virology、Journal of Biological Chemistry等期刊發(fā)表SCI論文22篇。主持國家十三五重點研發(fā)項目；部分成果被科技部入選“2019年度中國科學十大進展” ；獲農(nóng)業(yè)農(nóng)村部授予的個人嘉獎、第十五屆黑龍江省青年科技獎。
2、聯(lián)系方式
（1）研究方向：獸醫(yī)微生物及其分子生物學
（2）電話：0451-51051847
（3）郵箱：zhaodongming@caas.cn
（4）通訊地址：黑龍江省哈爾濱市香坊區(qū)哈平路678號
3、教育經(jīng)歷
2001.09-2006.06 東北農(nóng)業(yè)大學 動物醫(yī)學專業(yè) 學士
2006.09-2012.06 中國農(nóng)業(yè)科學院研究生院 預防獸醫(yī)學專業(yè) 博士（碩博連讀）
4、工作經(jīng)歷
2012.08-2013.12 日本學術(shù)振興機構(gòu) 博士后
2014.01-2016.06 東京大學醫(yī)科學研究所 博士后
2016.6-至今 中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所 科研骨干一級/研究員
2018.7-至今 中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所 “青年英才”院級入選者
2020.10-至今 中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所 創(chuàng)新團隊執(zhí)行首席
2020.10-至今 中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所 “農(nóng)科英才”領(lǐng)軍人才B類
2020.10-至今 中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所 中組部國家級青年人才
5、承擔項目
中組部國家級人才項目：2020.10-2023.10，170萬元，項目負責人；
國家十三五重點研發(fā)計劃：生物安全關(guān)鍵技術(shù)研發(fā)重點專項2018年度項目，總經(jīng)費1415萬元，2018.8-2021.6，項目負責人;
中國農(nóng)業(yè)科學院“農(nóng)科英才”領(lǐng)軍人才B類配套項目：非洲豬瘟病原生態(tài)學、致病機制及防控技術(shù)研究（2020.10-2025.10），500萬元；
獸醫(yī)生物技術(shù)國家重點實驗室自主課題：2018.01-2021.12，240萬元，項目負責人；
國家自然基金委非洲豬瘟重大基礎(chǔ)科學問題研究專項：非洲豬瘟病毒感染與致病機制（2019.07-2022.06）300萬元，主要參與人；
黑龍江省“頭雁行動計劃”：獸醫(yī)病毒學創(chuàng)新研究（2019.1-2023.12），團隊骨干。
6、代表論文與著作
Dongming Zhao*, Encheng Sun*, Lianyu Huang*, Leilei Ding*, Yuanmao Zhu*, Jiwen Zhang, Dongdong Shen, Xianfeng Zhang, Zhenjiang Zhang, Tao Ren, Wan Wang, Fang Li, Xijun He, Zhigao Bu# (2023). Highly lethal genotype I and II recombinant African swine fever viruses detected in pigs. Nat Commun. 2023 05 29;14 (1), 3096.
Yuhang Zhang*, Zhenjiang Zhang, Fan Zhang, Jiwen Zhang, Jun Jiao, Min Hou, Nianchao Qian, Dongming Zhao#, Xiaofeng Zheng#, Xu Tan# (2023). ASFV transcription reporter screening system identifies ailanthone as a broad antiviral compound. Virol Sin.2023 Jun, 38 (3), 459-469.
Yibrah Tekle Hagoss*, Dongdong Shen, Zhenjiang Zhang, Fang Li, Zhigao Bu#, Dongming Zhao# (2023). Novel Epitopes Mapping of African Swine Fever Virus CP312R Protein Using Monoclonal Antibodies. Viruses. 2023 02 17;15 (2)
Rong-Hong Hua*, Jing Liu*, Shu-Jian Zhang, Ren-Qiang Liu, Xian-Feng Zhang, Xi-Jun He, Dong-Ming Zhao#, Zhi-Gao Bu# (2023). Mammalian Cell-Line-Expressed CD2v Protein of African Swine Fever Virus Provides Partial Protection against the HLJ/18 Strain in the Early Infection Stage. Viruses. 2023 06 28;15(7).
Lulu Wang*, Dan Fu*, Weldu Tesfagaber, Fang Li, Weiye Chen, Yuanmao Zhu, Encheng Sun, Wan Wang, Xijun He, Yu Guo#, Zhigao Bu#, Dongming Zhao# (2022). Development of an ELISA Method to Differentiate Animals Infected with Wild-Type African Swine Fever Viruses and Attenuated HLJ/18-7GD Vaccine Candidate. Viruses.2022 Aug 6;14 (8)
Encheng Sun*, Lianyu Huang*, Xianfeng Zhang*, Jiwen Zhang*, Dongdong Shen*, Zhenjiang Zhang, Zilong Wang, Hong Huo, Wenqing Wang, Haoyue Huangfu, Wan Wang, Fang Li, Renqiang Liu, Jianhong Sun, Zhijun Tian, Wei Xia, Yuntao Guan, Xijun He, Yuanmao Zhu, Dongming Zhao#, Zhigao Bu#.(2021)."Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection." Emerg Microbes Infect: 1-30.
Encheng Sun*, Zhenjiang Zhang*, Zilong Wang*, Xijun He*, Xianfeng Zhang, Lulu Wang, Wenqing Wang, Lianyu Huang, Fei Xi, Haoyue Huangfu, Ghebremedhin Tsegay, Hong Huo, Jianhong Sun, Zhijun Tian, Wei Xia, Xuewu Yu, Fang Li, Renqiang Liu, Yuntao Guan, Dongming Zhao#, Zhigao Bu#. (2021). "Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020." Sci China Life Sci.
Xiaohui Ju*, Fang Li*, Jingrui Li*, Chunyan Wu, Guangtao Xiang, Xiaomin Zhao, Yuchen Nan, Dongming Zhao#, Qiang Ding#. (2021). "Genome-wide transcriptomic analysis of highly virulent African swine fever virus infection reveals complex and unique virus host interaction." Vet Microbiol 261: 109211.
Jiahao Lia*, Yun Bai*, Fang Li, Yue Zhang, Qingyun Xie, Lei Zhang, Lizhong Hua, Qiyan Xiong, Yanke Shan, Zhigao Bu, Guoqing Shao, Zhixin Feng#, Dongming Zhao#, FeiLiu#. (2021). "Rapid and ultra-sensitive detection of African swine fever virus antibody on site using QDM based-ASFV immunosensor (QAIS)." Analytica Chimica Acta 1189 (2022) 339187.
Wenzhuang Zhu, Kaiwen Meng, Yueping Zhang, Zhigao Bu, Dongming Zhao* and Geng Meng*. (2021). "Lateral Flow Assay for the Detection of African Swine Fever Virus Antibodies Using Gold Nanoparticle-Labeled Acid-Treated p72." Front Chem 9: 804981.
Weldu Tesfagaber*, Lulu Wang*, Ghebremedhin Tsegay, Yibrah Tekle Hagoss, Zhenjiang Zhang, Jiwen Zhang, Haoyue Huangf, Fei Xi, Fang Li, Encheng Sun, Zhigao Bu#, and Dongming Zhao#. (2021). "Characterization of Anti-p54 Monoclonal Antibodies and Their Potential Use for African Swine Fever Virus Diagnosis." Pathogens 10(2).
Yangming Song, Haixiang Huang, Yuzhen Hu, Jiwen Zhang, Fang Li, Xin Yin, Jianzhong Shi, Yanbing Li, Chengjun Li, Dongming Zhao*, Hualan Chen*. (2021). "A genome-wide CRISPR/Cas9 gene knockout screen identifies immunoglobulin superfamily DCC subclass member 4 as a key host factor that promotes influenza virus endocytosis." PLoS Pathog 17(12): e1010141.
Weiye Chen*, Dongming Zhao*, Xijun He*, Renqiang Liu*, Zilong Wang*, Xianfeng Zhang, Fang Li, Dan Shan, Hefeng Chen, Jiwen Zhang, Lulu Wang, Zhiyuan Wen, Xijun Wang, Yuntao Guan, Jinxiong Liu, Zhigao Bu (2020). "A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs." Sci China Life Sci 63(5): 623-634.
Dan Fu*, Dongming Zhao*, Wei Zhang*, Guangshun Zhang, Mingyu Li, Zheng Zhang, Yuhui Wang, Dongdong Sun, Peng Jiao, Cheng Chen, Yu Guo, Zihe Rao (2020). Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding. Protein Cell 11(8): 606-612.
Xing Liu*, Fang Li*, Jiwen Zhang, Lulu Wang, Jinliang Wang, Zhiyuan Wen, Zilong Wang, Lei Shuai, Xijun Wang, Jinying Ge, Dongming Zhao#, Zhigao Bu# (2020). The ATPase ATP6V1A facilitates rabies virus replication by promoting virion uncoating and interacting with the viral matrix protein." J Biol Chem.
Nan Wang*, Dongming Zhao*, Jialing Wang*, Yangling Zhang*, Ming Wang, Yan Gao, Fang Li, Jingfei Wang, Zhigao Bu, Zihe Rao, Xiangxi Wang. (2019). Architecture of African swine fever virus and implications for viral assembly. Science 366(6465): 640-644.
Dongming Zhao*, Renqiang Liu*, Xianfeng Zhang*, Fang Li*, Jingfei Wang, Jiwen Zhang, Xing Liu, Lulu Wang, Jiaoer Zhang, Xinzhou Wu, Yuntao Guan, Wenye Chen, Xijun Wang, Xijun He, Zhigao Bu. (2019). Replication and virulence in pigs of the first African swine fever virus isolated in China. Emerg Microbes Infect 8(1): 438-447.
Chunyang Gu; Xianying Zeng; Yangming Song; Yanbing Li; Liling Liu; Yoshihiro Kawaoka; Dongming Zhao#; Hualan Chen# (2018). Glycosylation and an amino acid insertion in the head of hemagglutinin independently affect the antigenic properties of H5N1 avian influenza viruses. Science China Life Sciences, 62(1): 76~83.
Dongming Zhao*, Libin Liang*, Shuai Wang, Nakao T, Yanbing Li, Liling Liu, Yuntao Guan, Fukuyama S, Zhigao Bu, Kawaoka Y, Hualan Chen. (2017). Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response. J Virol 91: e02215-02216.
Dongming Zhao, Satoshi Fukuyama, Yuko Sakai-Tagawa, Emi Takashita, Jason E Shoemaker and Yoshihiro Kawaoka. (2016). "C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, attenuates influenza A virus infection." Antimicrob Agents Chemother 60(3): 1902-1906.
Dongming Zhao, Satoshi Fukuyama, Shinya Yamada, Tiago J. S. Lopes, Tadashi Maemura, Hiroaki Katsura, Makoto Ozawa, Shinji Watanabe, Gabriele Neumann and Yoshihiro Kawaoka. (2015)."Molecular determinants of virulence and stability of a reporter-expressing H5N1 influenza A virus." J Virol 89(22): 11337-11346.
Satoshi Fukuyama*, Hiroaki Katsura*, Dongming Zhao*, Makoto Ozawa*, Tomomi Ando, Jason E. Shoemaker, Izumi Ishikawa, Shinya Yamada, Gabriele Neumann, Shinji Watanabe, Hiroaki Kitano, Yoshihiro Kawaoka. (2015). "Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies." Nat Commun 6: 6600.
Dongming Zhao, Libin Liang, Yanbing Li, Liling Liu, Yuntao Guan, Yongping Jiang, and Hualan Chen. (2012). "Proteomic analysis of the lungs of mice infected with different pathotypes of H5N1 avian influenza viruses." Proteomics 12(12): 1970-1982.
Dongming Zhao, Libin Liang, Yanbing Li, Liling Liu, Yongping Jiang, and Hualan Chen. "Phylogenetic and Pathogenic Analyses of Avian Influenza A H5N1 Viruses Isolated from Poultry in Vietnam." PLoS One 7(11): e50959.
7、獲獎情況
第十五屆黑龍江省青年科技獎，2022年；
農(nóng)業(yè)農(nóng)村部“關(guān)于糧食和生豬生產(chǎn)專項工作及時獎勵”的個人嘉獎，2022年；
“揭示非洲豬瘟病毒結(jié)構(gòu)及其組裝機制”榮獲科技部評選的“2019年度中國科學十大進展”，2020年；
發(fā)表在Emerging Microbes and Infections的論文獲得該雜志2019年度最佳論文獎, 排名第一。
8、授權(quán)發(fā)明專利
“基因缺失的減毒非洲豬瘟病毒及其作為疫苗的應(yīng)用”（ZL201910348878.7），排名第三。
一種檢測非洲豬瘟病毒抗體的膠體金免疫層析試紙卡（20211129182.1），排名第三。
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