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1、個(gè)人簡(jiǎn)介
吳洋,女,預(yù)防獸醫(yī)學(xué)博士,副研究員,碩士生導(dǎo)師。主要從事豬腸道冠狀病毒的致病機(jī)制、免疫機(jī)制、疫病防控技術(shù)研究等。黑龍江省高層次E類人才,主持“十四五”國(guó)家重點(diǎn)研發(fā)計(jì)劃子課題、黑龍江省博士后科研啟動(dòng)金、基本科研業(yè)務(wù)費(fèi)項(xiàng)目等;近年來(lái)以第一作者在PLoS Pathogens、Emerging Microbes & Infection、 Journal of Virology、Veterinary Microbiology等雜志發(fā)表文章10篇。
2、聯(lián)系方式
研究方向:獸醫(yī)微生物及其分子生物學(xué)
電話:0451-51051715
郵箱:wuyang@caas.cn
通訊地址:黑龍江省哈爾濱市香坊區(qū)哈平路678號(hào)
3、教育經(jīng)歷
2008.09-2012.06 東北農(nóng)業(yè)大學(xué) 動(dòng)物科學(xué)專業(yè) 學(xué)士
2012.09-2014.06 東北農(nóng)業(yè)大學(xué) 獸醫(yī)專業(yè) 碩士
2014.09-2017.12 東北農(nóng)業(yè)大學(xué) 預(yù)防獸醫(yī)學(xué)專業(yè) 博士
4、工作經(jīng)歷
2018.12-2023.12 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 助理研究員
2024.1-至今 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 副研究員
5、承擔(dān)項(xiàng)目
1.“十四五”國(guó)家重點(diǎn)研發(fā)計(jì)劃子課題:黑線姬鼠動(dòng)物模型的建立,2024年1月至2028年12月,項(xiàng)目編號(hào):2023YFF0724603-5,30萬(wàn)元,子課題主持人;
2. 黑龍江省博士后科研啟動(dòng)金項(xiàng)目:POLDIP3調(diào)控豬腹瀉病毒復(fù)制的分子機(jī)制研究,2023年7月至2025年7月,10萬(wàn)元,項(xiàng)目主持人;
6. 代表性論文
1. Wu Y, Li M, Tian J, Yan H, Pan Y, Shi H, et al. Broad antagonism of coronaviruses nsp5 to evade the host antiviral responses by cleaving POLDIP3. PLoS Pathog. 2023;19(10):e1011702.
2. Li M#, Wu Y#, Tian J, Yang Q, Gao M, Wang Y, et al. Nuclear shuttling of CDC4 mediated broad-spectrum antiviral activity against diverse coronaviruses. Emerg Microbes Infect. 2025;14(1):2493922.
3. Li M#, Wu Y#, Chen J, Shi H, Ji Z, Zhang X, et al. Innate Immune Evasion of Porcine Epidemic Diarrhea Virus through Degradation of the FBXW7 Protein via the Ubiquitin-Proteasome Pathway. J Virol. 2022;96(5):e0088921.
4. Wu Y, Shi Z, Chen J, Zhang H, Li M, Zhao Y, et al. Porcine deltacoronavirus E protein induces interleukin-8 production via NF-kappaB and AP-1 activation. Vet Microbiol. 2022;274:109553.
5. Wu Y, Wang Y, Wang X, Li M, Yan H, Shi H, et al. Elevation of IL-8 secretion induced by PEDV infection via NF-kappaB signaling pathway. Front Cell Infect Microbiol. 2024;14:1422560.
6. Wu Y, Zhang H, Chen J, Shi Z, Li M, Zhao Y, et al. Stromal Antigen 2 Deficiency Induces Interferon Responses and Restricts Porcine Deltacoronavirus Infection. Viruses. 2022;14(8).
7. Wu Y, Zhang H, Shi Z, Chen J, Li M, Shi H, et al. Porcine Epidemic Diarrhea Virus nsp15 Antagonizes Interferon Signaling by RNA Degradation of TBK1 and IRF3. Viruses. 2020;12(6).
8. Quan F, Geng Y, Wu Y, Jiang F, Li X, Yu C. Development and application of a quadruplex real-time PCR method for Torque teno sus virus 1, Porcine circovirus type 2, pseudorabies virus, and porcine parvovirus. Front Cell Infect Microbiol. 2024;14:1461448.
9. Wu Y, Guo M, Hua X, Duan K, Lian G, Sun L, et al. The role of infectious hematopoietic necrosis virus (IHNV) proteins in the modulation of NF-kappaB pathway during IHNV infection. Fish Shellfish Immunol. 2017;63:500-6.
10. Wu Y, Wang L, Guo T, Jiang Y, Qiao X, Sun L, et al. Identification of amino acid residues in infectious hematopoietic necrosis virus (IHNV) NV protein necessary for viral replication and pathogenicity. Fish Shellfish Immunol. 2018;79:294-302.
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