1、個人簡歷
石達,男,農(nóng)學(xué)博士,碩士研究生導(dǎo)師,副研究員,豬消化道傳染病創(chuàng)新團隊成員,一直從事豬冠狀病毒基礎(chǔ)與應(yīng)用研究。近年來以第一作者發(fā)表SCI論文16篇;主持或參與國家自然科學(xué)基金聯(lián)合基金、國家自然科學(xué)基金青年基金項目、黑龍江省自然科學(xué)基金面上項目、中國博士后科學(xué)基金項目(一等資助),以及廣西獸醫(yī)生物技術(shù)重點實驗室開放基金項目各1項;獲中國農(nóng)業(yè)科學(xué)院成果轉(zhuǎn)化獎(排名第5)、中國農(nóng)業(yè)科學(xué)院技術(shù)成果獎(排名第9)、黑龍江省科學(xué)技術(shù)發(fā)明一等獎(排名第9)各1項。
2、聯(lián)系方式
研究方向:獸醫(yī)微生物及其分子生物學(xué)
電話:13654566563
郵箱:shida@caas.cn
所在單位:中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所
通訊地址:哈爾濱市香坊區(qū)哈平路678號
3、教育經(jīng)歷
2005.09-2009.06 河北北方學(xué)院 動物醫(yī)學(xué)專業(yè) 學(xué)士
2009.09-2012.06 中國農(nóng)業(yè)科學(xué)院研究生院 預(yù)防獸醫(yī)學(xué)專業(yè) 碩士
2012.09-2015.07 中國農(nóng)業(yè)科學(xué)院研究生院 預(yù)防獸醫(yī)學(xué)專業(yè) 博士
4、工作經(jīng)歷
2015.07-2017.12 中國農(nóng)科院哈爾濱獸醫(yī)研究所 助理研究員
2018.01-今 中國農(nóng)科院哈爾濱獸醫(yī)研究所 副研究員
5、承擔(dān)項目
1. 國家自然科學(xué)基金聯(lián)合基金項目(U23A20236):畜禽冠狀病毒S蛋白雙受體識別及其分子基礎(chǔ),2024/01-2027/12,255萬元,在研,主要參與。
2. 國家自然科學(xué)基金青年科學(xué)基金項目:微管正端示蹤蛋白EB3對PEDV復(fù)制的調(diào)控作用及其分子機制(31602072,2017.01-2019.12),20萬元。
3. 黑龍江省科學(xué)基金面上項目:豬流行性腹瀉病毒NSP1蛋白抑制宿主基因表達的分子機制(C2017079,2017.10-2020.10),6萬元。
4. 中國博士后科學(xué)基金面上項目(一等資助):分子伴侶蛋白HSP47對PEDV復(fù)制的調(diào)控作用及其分子機制(2017M610136,2017.01-2018.12),8萬元。
6、代表論文與著作
1. Zhang J*, Zhang L*, Liu D*, Shi H, Zhang X, Chen J, Yang X, Zeng M, Zhang J, Feng T, Zhu X, Jing Z, Ji Z, Shi D*, Feng L*. Helicase protein DDX11 as a novel antiviral factor promoting RIG-I-MAVS-mediated signaling pathway. mBio. 2024 Dec 11;15(12):e0202824. (共同通訊,IF:5.1)
2. Zhang J, Shi H, Zhang L, Feng T, Chen J, Zhang X, Ji Z, Jing Z, Zhu X, Liu D, Yang X, Zeng M, Shi D*, Feng L*. Swine acute diarrhea syndrome coronavirus nucleocapsid protein antagonizes the IFN response through inhibiting TRIM25 oligomerization and functional activation of RIG-I/TRIM25. Vet Res. 2024 Apr 8;55(1):44. (共同通訊,IF:3.7)
3. Zhang L*, Yang X*, Shi H, Zhang J, Feng T, Liu D, Zhang X, Chen J, Shi D*, Feng L*. Identification of two novel B-cell epitopes located on the spike protein of swine acute diarrhea syndrome coronavirus. Int J Biol Macromol. 2024 Oct;278(Pt 4):135049. (共同通訊,IF:7.7)
4. Shi, D., Zhou, L., Shi, H., Zhang, J., Zhang, L., Liu, D., Feng, T., Zeng, M., Chen, J., Zhang, X., Xue, M., Jing, Z., Liu, J., Ji, Z., He, H., Guo, L., Wu, Y., Ma, J., Feng, L. Autophagy is induced by swine acute diarrhea syndrome coronavirus through the cellular IRE1-JNK-Beclin 1 signaling pathway after an interaction of viral membrane-associated papain-like protease and GRP78. PLoS Pathog. 2023 Mar 8;19(3):e1011201(第一作者,IF:6.7)
5. Zhang, J., Zhang, L., Shi, H., Feng, S., Feng, T., Chen, J., Zhang, X., Han, Y., Liu, J., Wang, Y., Ji, Z., Jing, Z., Liu, D., Shi, D*., Feng, L*., 2022. Swine acute diarrhea syndrome coronavirus replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway. Virology 565, 96-105. (共同通訊)
6. Qin, Y., Feng, T., Shi, H., Zhang, J., Zhang, L., Feng, S., Chen, J., He, Y., Zhang, X., Chen, Z., Liu, J., Liu, D., Shi, D*., Feng, L*., 2022. Identification and epitope mapping of swine acute diarrhea syndrome coronavirus accessory protein NS7a via monoclonal antibodies. Virus research 313, 198742. (共同通訊)
7. Su, M#., Shi, D#., Xing, X., Qi, S., Yang, D., Zhang, J., Han, Y., Zhu, Q., Sun, H., Wang, X., Wu, H., Wang, M., Wei, S., Li, C., Guo, D., Feng, L., Sun, D., 2021. Coronavirus PEDV nucleocapsid protein interacts with p53 to induce cell cycle arrest in S-phase and promotes viral replication. Journal of virology, JVI0018721.(共同第一作者)
8. Ji, Z#., Shi, D#., Shi, H., Wang, X., Chen, J., Liu, J., Ye, D., Jing, Z., Liu, Q., Fan, Q., Li, M., Cong, G., Zhang, J., Han, Y., Zhang, X., Feng, L*., 2021. A porcine epidemic diarrhea virus strain with distinct characteristics of four amino acid insertion in the COE region of spike protein. Veterinary microbiology 253, 108955.(共同第一作者)
9. Wei, S#., Shi, D#., Wu, H., Sun, H., Chen, J., Feng, L., Su, M., Sun, D., 2021. Identification of a novel B cell epitope on the nucleocapsid protein of porcine deltacoronavirus. Virus research 302, 198497. (共同第一作者)
10. Zhang, J., Han, Y., Shi, H., Chen, J., Zhang, X., Wang, X., Zhou, L., Liu, J., Ji, Z., Jing, Z., Ma, J., Shi, D*., Feng, L*., 2020. Swine acute diarrhea syndrome coronavirus-induced apoptosis is caspase- and cyclophilin D- dependent. Emerging Microbes & Infections 9, 439-456. (共同通訊)
11. Han, Y., Zhang, J., Shi, H., Zhou, L., Chen, J., Zhang, X., Liu, J., Wang, X., Ji, Z., Jing, Z., Cong, G., Ma, J., Shi, D*., Li, F*., 2019. Epitope mapping and cellular localization of swine acute diarrhea syndrome coronavirus nucleocapsid protein using a novel monoclonal antibody. Virus research 273, 197752. (共同通訊)
12. Shi, D., Wang, X., Shi, H., Zhang, J., Han, Y., Chen, J., Zhang, X., Liu, J., Ji, Z., Jing, Z., Feng, L*., 2019. Significant Interference with Porcine Epidemic Diarrhea Virus Pandemic and Classical Strain Replication in Small-Intestine Epithelial Cells Using an shRNA Expression Vector. Vaccines 7.
13. Shi, D., Shi, H., Sun, D., Chen, J., Zhang, X., Wang, X., Zhang, J., Ji, Z., Liu, J., Cao, L., Zhu, X., Yuan, J., Dong, H., Chang, T., Liu, Y., Feng, L*., 2017. Nucleocapsid Interacts with NPM1 and Protects it from Proteolytic Cleavage, Enhancing Cell Survival, and is Involved in PEDV Growth. Scientific reports 7, 39700.
14. Shi, D., Lv, M., Chen, J., Shi, H., Zhang, S., Zhang, X., Feng, L*., 2014. Molecular characterizations of subcellular localization signals in the nucleocapsid protein of porcine epidemic diarrhea virus. Viruses 6, 1253-1273.
15. Shi, D., Zhang, S., Chen, J., Shi, H., Zhang, X., Feng, L*., 2013. Molecular characterization of a porcine kobuvirus variant strain in China. Archives of virology 158, 2379-2383.
7、獲得獎勵
1. 2021-2022年度“優(yōu)秀共產(chǎn)黨員”榮譽稱號。
2. 2019年度文明職工標(biāo)兵。
3. 中國農(nóng)業(yè)科學(xué)院2017年度優(yōu)秀博士后稱號。
4. “豬傳染性胃腸炎、豬流行性腹瀉、豬輪狀病毒(G5型)三聯(lián)活疫苗”的研制,中國農(nóng)業(yè)科學(xué)院科學(xué)技術(shù)成果獎(杰出科技創(chuàng)新獎),馮力,時洪艷,陳建飛,佟有恩,張鑫,王洪峰,王牟平,孫東波,石達,2016。
5. 豬傳染性胃腸炎、豬流行性腹瀉、豬輪狀病毒(G5型)三聯(lián)活疫苗創(chuàng)制與應(yīng)用,黑龍江省科學(xué)技術(shù)獎(技術(shù)發(fā)明類一等獎),馮力,時洪艷,陳建飛,佟有恩,張鑫,王洪峰,王牟平,孫東波,石達,2017。
6. 中國農(nóng)業(yè)科學(xué)院成果轉(zhuǎn)化獎,馮力,時洪艷,陳建飛,張鑫,石達,危艷武,黃立平,郭龍軍,薛美,田進,符芳,吳洋,李亮。