走進(jìn)哈獸研
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1、個(gè)人簡(jiǎn)歷
張洪亮，博士，副研究員。主要從事豬藍(lán)耳病及豬病新發(fā)病原的流行病學(xué)和防控技術(shù)研究，2015年首次分離和報(bào)道2.1d新亞型豬瘟病毒，評(píng)價(jià)了C株對(duì)2.1d新亞型豬瘟病毒的保護(hù)效果。2016年完成了類(lèi)NADC30 PRRSV的致病性及當(dāng)前疫苗的保護(hù)效果，研制了針對(duì)類(lèi)NADC30 PRRSV的疫苗候選株。2018年首次分離和報(bào)道我國(guó)出現(xiàn)類(lèi)NADC34（1-7-4分支）豬藍(lán)耳病病毒，并評(píng)價(jià)了類(lèi)NADC34 PRRSV的致病性及在我國(guó)的流行情況。參與類(lèi)NADC30豬繁殖與呼吸綜合征活疫苗（SD-R株）創(chuàng)制和豬偽狂犬病活疫苗（TP株）創(chuàng)制。主持國(guó)家自然基金1項(xiàng)，博士后基金1項(xiàng)，黑龍江省自然基金1項(xiàng)。以第一作者（含共第一）和通訊作者（含共通訊）發(fā)表論文43篇，其中SCI論文27篇，中文核心論文16篇。
2、聯(lián)系方式
研究方向：動(dòng)物疫苗與分子免疫學(xué)
電話(huà)：13624503578
郵箱：zhanghongliang01@caas.cn
通訊地址：哈爾濱市香坊區(qū)哈平路678號(hào)
3、教育經(jīng)歷
2009.09～2013.06 青島農(nóng)業(yè)大學(xué)動(dòng)物醫(yī)學(xué)專(zhuān)業(yè) 學(xué)士
2013.09～2016.06 中國(guó)農(nóng)業(yè)科學(xué)院預(yù)防獸醫(yī)學(xué)專(zhuān)業(yè) 碩士
2016.09～2019.06 中國(guó)農(nóng)業(yè)科學(xué)院預(yù)防獸醫(yī)學(xué)專(zhuān)業(yè) 博士
2019.07～2023.04 中國(guó)農(nóng)業(yè)科學(xué)院 博士后
4、工作經(jīng)歷
2023.05～ 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 副研究員
5、承擔(dān)項(xiàng)目
1. 國(guó)家自然基金青年科學(xué)基金項(xiàng)目：I型和II型豬繁殖與呼吸綜合征病毒抗體鑒別診斷靶點(diǎn)篩選及鑒定（32002315），24萬(wàn)元。
2. 第68批博士后基金：豬繁殖與呼吸綜合征活疫苗交叉保護(hù)的分子機(jī)制（2020M680788），8萬(wàn)元。
3. 黑龍江省自然科學(xué)基金優(yōu)秀青年項(xiàng)目：豬繁殖與呼吸綜合征病毒活疫苗誘導(dǎo)豬體抗體應(yīng)答差異的分子機(jī)制（YQ2022C042），10萬(wàn)元。
4. 國(guó)家生豬技術(shù)創(chuàng)新中心牧原項(xiàng)目：歐洲型PRRSV抗原抗體鑒別診斷方法建立（NCTIP-MY23001），30萬(wàn)元。
6、代表論文
1. Zhang H, Feng L, Liu C, Chen J, Leng C, Bai Y, Peng J, An T, Cai X, Yang X, Tian Z, Tong G. Complete Genome Sequence of Classical Swine Fever Virus Strain JSZL, Belonging to a New Subgenotype, 2.1d, Isolated in China in 2014. Genome Announc. 2015 Aug 20;3(4):e00833-15. (First author)
2. Zhang H., Leng, C., Feng, L., Zhai, H., Chen, J., Liu, C., Bai, Y., Ye, C., Peng, J., An, T., Kan, Y., Cai, X., Tian, Z., Tong, G., 2015. A new subgenotype 2.1d isolates of classical swine fever virus in China, 2014. Infect Genet Evol 34, 94-105. (First author)
3. Zhang, H.L., Zhang, W.L., Xiang, L.R., Leng, C.L., Tian, Z.J., Tang, Y.D., Cai, X.H., 2018. Emergence of novel porcine reproductive and respiratory syndrome viruses (ORF5 RFLP 1-7-4 viruses) in China. Vet Microbiol 222, 105-108. (First author)
4. Zhang H, Leng C, Ding Y, Zhai H, Li Z, Xiang L, Zhang W, Liu C, Li M, Chen J, Bai Y, Kan Y, Yao L, Peng J, Wang Q, Tang YD, An T, Cai X, Tian Z, Tong G. Characterization of newly emerged NADC30-like strains of porcine reproductive and respiratory syndrome virus in China. Arch Virol. 2019 Feb;164(2):401-411. (First author)
5. Zhang WL, Zhang HL, Xu H, Tang YD, Leng CL, Peng JM, Wang Q, An TQ, Cai XH, Fan JH, Tian ZJ. Two novel recombinant porcine reproductive and respiratory syndrome viruses belong to sublineage 3.5 originating from sublineage 3.2. Transbound Emerg Dis. 2019 Nov;66(6):2592-2600. (Co-first author)
6. Xu H, Song S, Zhao J, Leng C, Fu J, Li C, Tang YD, Xiang L, Peng J, Wang Q, Zhao H, An T, Cai X, Zhang H, Tian ZJ. A potential endemic strain in China: NADC34-like porcine reproductive and respiratory syndrome virus. Transbound Emerg Dis. 2020 Jul;67(4):1730-1738. (Co-corresponding author)
7. Song S, Xu H, Zhao J, Leng C, Xiang L, Li C, Fu J, Tang YD, Peng J, Wang Q, Zhao H, An T, Cai X, Zhang H, Tian ZJ. Pathogenicity of NADC34-like PRRSV HLJDZD32-1901 isolated in China. Vet Microbiol. 2020 Jul;246:108727. (Co-corresponding author)
8. Zhang HL, Li YM, Sun J, Zhang YY, Wang TY, Sun MX, Wang MH, Yang YL, Hu XL, Tang YD, Zhao J, Cai X. Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species. J Biol Chem. 2021 Jan-Jun;296:100435. (First author)
9. Li C, Gong B, Sun Q, Xu H, Zhao J, Xiang L, Tang YD, Leng C, Li W, Guo Z, Fu J, Peng J, Wang Q, Zhou G, Yu Y, Meng F, An T, Cai X, Tian ZJ, Zhang H. First Detection of NADC34-like PRRSV as a Main Epidemic Strain on a Large Farm in China. Pathogens. 2021 Dec 29;11(1):32. (Corresponding author)
10. Xu H, Li C, Li W, Zhao J, Gong B, Sun Q, Tang YD, Xiang L, Leng C, Peng J, Wang Q, Meng F, Yu Y, An T, Cai X, Tian ZJ, Zhang H. Novel characteristics of Chinese NADC34-like PRRSV during 2020-2021. Transbound Emerg Dis. 2022 Sep;69(5):e3215-e3224. (Corresponding author)
11. Xu H, Xiang L, Tang YD, Li C, Zhao J, Gong B, Sun Q, Leng C, Peng J, Wang Q, Zhou G, An T, Cai X, Tian ZJ, Zhang H, Song M. Genome-Wide Characterization of QYYZ-Like PRRSV During 2018-2021. Front Vet Sci. 2022 Jun 30;9:945381. (Co-corresponding author)
12. Xiang L, Xu H, Li C, Tang YD, An TQ, Li Z, Liu C, Song S, Zhao J, Leng C, Qu X, Sun Y, Peng J, Wang Q, Cai X, Tian ZJ, Zhang H. Long-Term Genome Monitoring Retraces the Evolution of Novel Emerging Porcine Reproductive and Respiratory Syndrome Viruses. Front Microbiol. 2022 Apr 13;13:885015. (Corresponding author)
13. Sun Q, Xu H, Li C, Gong B, Li Z, Tian ZJ, Zhang H. Emergence of a novel PRRSV-1 strain in mainland China: A recombinant strain derived from the two commercial modified live viruses Amervac and DV. Front Vet Sci. 2022 Sep 9;9:974743. (Corresponding author)
14. Zhang H, Xiang L, Xu H, Li C, Tang YD, Gong B, Zhang W, Zhao J, Song S, Peng J, Wang Q, An T, Cai X, Tian ZJ. Lineage 1 Porcine Reproductive and Respiratory Syndrome Virus Attenuated Live Vaccine Provides Broad Cross-Protection against Homologous and Heterologous NADC30-Like Virus Challenge in Piglets. Vaccines (Basel). 2022 May 10;10(5):752. (First author)
15. Li C, Xu H, Zhao J, Gong B, Sun Q, Xiang L, Li W, Guo Z, Li J, Tang YD, Leng C, Peng J, Wang Q, An T, Cai X, Tian ZJ, Zhou G, Zhang H. Epidemiological investigation and genetic evolutionary analysis of PRRSV-1 on a pig farm in China. Front Microbiol. 2022 Dec 1;13:1067173. (Corresponding author)
16. Guo Z, Zhang S, Xu H, Li W, Li C, Zhao J, Gong B, Sun Q, Xiang L, Zhao H, Wang Q, Zhou G, Tang Y, An T, Cai X, Tian Z, Zhang H, Peng J. Preparation and Identification of a Monoclonal Antibody against the Pseudorabies Virus gE Glycoprotein through a Novel Strategy. Vet Sci. 2023 Feb 9;10(2):133. (Co-corresponding author)
17. Xu H, Gong B, Sun Q, Li C, Zhao J, Xiang L, Li W, Guo Z, Tang Y, Leng C, Li Z, Wang Q, Zhou G, An T, Cai X, Tian Z, Peng J, Zhang H. Genomic Characterization and Pathogenicity of BJEU06-1-Like PRRSV-1 ZD-1 Isolated in China, Transbound Emerg Dis, vol. 2023, Article ID 6793604, 12 pages, 2023. (Corresponding author)
18. Li W, Li C, Guo Z, Xu H, Gong B, Sun Q, Zhao J, Xiang L, Leng C, Peng J, Zhou G, Tang Y, Liu H, An T, Cai XH, Tian ZJ, Wang Q, Zhang H. Genomic characteristics of a novel emerging PRRSV branch in sublineage 8.7 in China. Front Microbiol. 2023 May 31;14:1186322. (Corresponding author)
19. Sun Q, Xu H, An T, Cai X, Tian Z, Zhang H. Recent Progress in Studies of Porcine Reproductive and Respiratory Syndrome Virus 1 in China. Viruses. 2023 Jul 10;15(7):1528. (Corresponding author)
20. Xu H, Li C, Gong B, Li W, Guo Z, Sun Q, Zhao J, Xiang L, Li J, Tang YD, Leng C, Wang Q, Peng J, Zhou G, Liu H, An T, Cai X, Tian ZJ, Zhang H. Protective Efficacy of a Candidate Live-Attenuated Vaccine Derived from the SD-R Strain against NADC34-like Porcine Reproductive and Respiratory Syndrome Virus. Vaccines (Basel). 2023 Aug 9;11(8):1349. (Corresponding author)
21. Zhang H, Li C, Xu H, Gong B, Li W, Guo Z, Xiang L, Sun Q, Zhao J, Peng J, Wang Q, Zhou G, Tang Y-D, An T, Cai X-H, Tian Z-J. Protective efficacy of a candidate live attenuated vaccine derived from the SD-R strain of lineage 1 porcine reproductive and respiratory syndrome virus against a lethal challenge with HP-PRRSV HuN4 in piglets. Microbiol Spectr. 2023 Dec 12;11(6):e0198423. (First author)
22. Li C, Zhao J, Li W, Xu H, Gong B, Sun Q, Guo Z, Li J, Xiang L, Tang YD, Leng C, Wang Q, Peng J, Zhou G, Liu H, An T, Cai X, Tian ZJ, Zhang H. Prevalence and genetic evolution of porcine reproductive and respiratory syndrome virus in commercial fattening pig farms in China. Porcine Health Manag. 2024 Jan 22;10(1):5. (Corresponding author)
23. Guo Z, Xu H, Zhang S, Kang H, Li C, Sun Q, Zhao J, Li J, Zhou G, Wang Q, Xiang L, Tang Y, Liu H, Leng C, An T, Cai X, Tian Z, Zhang H, Peng J. Improved detection sensitivity of anti-PRV variant antibodies through preparation of anti-gB and anti-gE monoclonal antibodies and development of blocking ELISAs. Int J Biol Macromol. 2024 Mar;260(Pt 1):129425. (Co-corresponding author)
24. Gong B, Xu H, Sun Q, Li C, Xiang L, Zhao J, Li W, Guo Z, Li J, Wang Q, Peng J, Zhou G, Leng C, Tang YD, Wu J, Liu H, An TQ, Cai X, Tian ZJ, Zhang H, Dissecting Genetic Diversity and Evolutionary Trends of Chinese PRRSV-1 Based on Whole-Genome Analysis, Transboundary and Emerging Diseases, 2024, 9705539, 15 pages, 2024. (Corresponding author)
25. Li J, Xu H, Li C, Zhao J, Gong B, Sun Q, Guo Z, Zhang S, Zhang M, Xiang L, Tang Y, Wu J, Wang Q, Peng J, Zhou G, Liu H, An T, Cai X, Tian ZJ, Zhang H, Genomic Characterization of HLJDZD55: The First L1B PRRSV in China, Transboundary and Emerging Diseases, 2024, 2969771, 8 pages, 2024. (Corresponding author)
26. Xu H, Zhang S, Guo Z, Li C, Gong B, Li J, Sun Q, Zhao J, Zhang M, Xiang L, Tang Y, Leng C, Wu J, Wang Q, Peng J, Zhou G, Liu H, An T, Cai X, Tian Z, Zhang H. Novel characterization of NADC30-like and NADC34-like PRRSV strains in China: epidemiological status and pathogenicity analysis of L1A variants, Journal of Integrative Agriculture, https://doi.org/10.1016/j.jia.2024.03.056(Corresponding author)
27. Li C, Li J, Gong B, Xu H, Guo Z, Xiang L, Zhang S, Sun Q, Zhao J, Zhang M, Tang YD, Leng C, Wu J, Wang Q, Peng J, Zhou G, Liu H, An T, Cai X, Tian ZJ, Zhang H. A lineage 1 branch porcine reproductive and respiratory syndrome virus live vaccine candidate provides broad cross-protection against HP-like PRRSV in piglets. Virulence. 2025 Dec;16(1):2451754. (Corresponding author)
7、專(zhuān)利和標(biāo)準(zhǔn)
1. 發(fā)明人：田志軍，張洪亮，蔡雪輝，相麗潤(rùn)，王倩，湯艷東，彭金美，安同慶 專(zhuān)利名稱(chēng)：類(lèi)NADC30豬藍(lán)耳病強(qiáng)毒株、弱毒株及其應(yīng)用。專(zhuān)利號(hào)：202010580477.7
2. 發(fā)明人：田志軍，張洪亮，許滸，相麗潤(rùn)，彭金美，王倩，周?chē)?guó)輝，蔡雪輝，湯艷東，安同慶 專(zhuān)利名稱(chēng)：分泌歐洲型PRRSV特異性單克隆抗體的雜交瘤細(xì)胞系EU1及其競(jìng)爭(zhēng)ELISA方法的建立。專(zhuān)利號(hào)：202110995235.9
3. 發(fā)明人：張洪亮，田志軍，王倩，彭金美，周?chē)?guó)輝 專(zhuān)利名稱(chēng)：一種分泌高致病性豬繁殖與呼吸綜合征病毒特異性單克隆抗體的雜交瘤細(xì)胞株及其應(yīng)用。專(zhuān)利號(hào)：202311001871.0
4. 發(fā)明人：彭金美，田志軍，張洪亮，王倩，周?chē)?guó)輝 專(zhuān)利名稱(chēng)：一種分泌抗豬偽狂犬病病毒gB蛋白抗體的單克隆雜交瘤細(xì)胞株及其應(yīng)用。專(zhuān)利號(hào)：202310770698.4
8、獲得獎(jiǎng)勵(lì)
1. 獲評(píng)為中國(guó)農(nóng)業(yè)科學(xué)院2020年度第二批優(yōu)秀博士后。
2. 獲得第十三屆中國(guó)創(chuàng)新創(chuàng)業(yè)大賽創(chuàng)新挑戰(zhàn)賽（重慶）生豬技術(shù)專(zhuān)業(yè)賽金獎(jiǎng)。
3. 獲得黑龍江省首屆環(huán)大學(xué)大院大所創(chuàng)新創(chuàng)業(yè)生態(tài)圈科技成果擂臺(tái)賽三等獎(jiǎng)。
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