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1、個(gè)人簡(jiǎn)歷
杜承，男，1981年生，山西大同人，中共黨員，博士，副研究員，碩士生導(dǎo)師，中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所馬傳染病與慢病毒病創(chuàng)新團(tuán)隊(duì)科研骨干，中國(guó)獸醫(yī)協(xié)會(huì)團(tuán)隊(duì)標(biāo)準(zhǔn)技術(shù)委員會(huì)馬病診療分委會(huì)副主任委員，中國(guó)農(nóng)業(yè)科學(xué)院“科研英才培育工程”所級(jí)入選者，吉林省人獸共患病學(xué)會(huì)理事，主要從事馬屬動(dòng)物病毒分子免疫方向和馬屬動(dòng)物寄生蟲(chóng)防控技術(shù)的研究。目前主持國(guó)家自然基金面上項(xiàng)目2項(xiàng)，青年項(xiàng)目1項(xiàng)，黑龍江省自然基金面上項(xiàng)目1項(xiàng)，國(guó)家重點(diǎn)研發(fā)計(jì)劃子課題2項(xiàng)，參加其他省部級(jí)項(xiàng)目近10項(xiàng)，在Jounal of Virology、Science China life sciences、Transbounding Emerging Dis和Microbiology Spectrum等國(guó)際知名學(xué)術(shù)期刊上發(fā)表SCI論文20余篇，獲得省部級(jí)一等獎(jiǎng)2項(xiàng)、二等獎(jiǎng)1項(xiàng)，三等獎(jiǎng)2項(xiàng)、國(guó)家發(fā)明專利1項(xiàng)、參編專著3部。
2、聯(lián)系方式
單位：中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所
地址：黑龍江省哈爾濱市南崗區(qū)哈平路678號(hào)
電話：0451-51051752（辦公室）
郵箱： ducheng@caas.cn
3、教育經(jīng)歷
2000.09-2004.06 天津商業(yè)大學(xué) 生物工程專業(yè) 工學(xué)學(xué)士
2005.09-2007.06 吉林大學(xué) 微生物專業(yè) 理學(xué)碩士
2007.09-2010.06 吉林大學(xué) 人獸共患疫病學(xué)專業(yè) 農(nóng)學(xué)博士
4、工作經(jīng)歷
2010.07-2015.12 中國(guó)農(nóng)科院哈爾濱獸醫(yī)研究所 助理研究員
2016.01-至今 中國(guó)農(nóng)科院哈爾濱獸醫(yī)研究所 副研究員
5、 承擔(dān)主要項(xiàng)目
1. 國(guó)家自然科學(xué)基金面上項(xiàng)目：馬傳染性貧血病強(qiáng)弱毒株感染造成靶細(xì)胞線粒體損傷差異的研究（31572537，2016.01-2019.12），76.8萬(wàn)元，主持；
2. 國(guó)家自然科學(xué)基金面上項(xiàng)目：miR-27a和miR-92a在EIAV強(qiáng)弱毒誘導(dǎo)宿主差異炎癥反應(yīng)中的作用機(jī)制研究（31772720，2018.01-2021.12），68.4萬(wàn)元，主持；
3. “十三五” 國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目：畜禽重要胞內(nèi)寄生原蟲(chóng)的寄生與免疫機(jī)制研究（2017YFD0500400，2017.07 -2020.12），子課題，47萬(wàn)元，主持；
4. “十四五” 國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目：動(dòng)物重要寄生蟲(chóng)的生長(zhǎng)發(fā)育與寄生機(jī)制（2022YFD1800200，2022.11 -2025.12），子課題，63萬(wàn)元，主持；
5. 國(guó)家自然科學(xué)基金青年基金項(xiàng)目：馬傳染性貧血病毒弱毒疫苗株與強(qiáng)毒株感染對(duì)靶細(xì)胞作用差異的研究（31201906，2013.01-2015.12），23萬(wàn)元，主持；
6. 黑龍江省自然科學(xué)基金面上項(xiàng)目：microRNA在EIAV強(qiáng)弱毒誘導(dǎo)宿主差異炎癥反應(yīng)中的作用機(jī)制研究（C2018071，2018.07-2021.07），6萬(wàn)元，主持；
7. 中國(guó)博士后科學(xué)基金項(xiàng)目：馬傳貧病毒強(qiáng)弱毒株感染后靶細(xì)胞差異應(yīng)答蛋白的研究（2013M541335），5萬(wàn)元，主持；
8. 黑龍江省博士后科學(xué)基金項(xiàng)目：馬傳貧病毒強(qiáng)弱毒株感染后靶細(xì)胞差異應(yīng)答蛋白的研究（LRB12-448），2萬(wàn)元，主持；
9. 國(guó)家自然科學(xué)基金國(guó)際(地區(qū))合作與交流項(xiàng)目：對(duì)巨噬細(xì)胞HIV病毒儲(chǔ)庫(kù)的清除策略研究（81561128010，2016.01-2018.12），300萬(wàn)元，參加；
10. 十二五”國(guó)家重大科技專項(xiàng)：創(chuàng)新性復(fù)制和非復(fù)制載體艾滋病疫苗研究（2012ZX10001-008，2013.01-2015.12），135萬(wàn)元，參加。
6、代表性論文與著作
論文：
1. Cheng Du，Yinyi Duan，Xue-Feng Wang，Yue-Zhi Lin，Lei Na，Xinhui Wang，Kewei Chen，Xiaojun Wang*. Attenuation of Equine Lentivirus Alters Mitochondrial Protein Expression Profile from Inflammation to Apoptosis. J Virol. 2019 Oct15;93(21): e00653-19.
2. Yinyi Duan，Xinhui Wang, Kehui Sun, Yue-Zhi Lin，Xue-Feng Wang，Kewei Chen，Guangpu Yang, Xiaojun Wang*, Cheng Du*. SYNJ2BP Improves the Production of Lentiviral Envelope Protein by Facilitating the Formation of Mitochondrion-Associated Endoplasmic Reticulum Membrane. J Virol. 2022 Oct 26;96(20): e0054922.
3. Kewei Chen，Zhe Hu, Jingkun Li, Jingfei Wang, Diqiu Liu, Ting Qi, Wei Guo, Cheng Du*, Xiaojun Wang*. Prevalence and molecular epidemiology of equine piroplasmosis in China: a neglected tick-borne disease. Sci China Life Sci. 2022 Feb;65(2):445-447.
4. Jun Zheng#, Wenqiang Su#, Shinuo Cao, Zhaoxia Zhang, Cheng Du#, Honglin Jia*. TgMAP1c is involved in apicoplast biogenesis in Toxoplasma gondii. Int J Parasitol. 2020 Jun;50(6-7):487-499.
5. Guangpu Yang, Kewei Chen, Wei Guo, Zhe Hu, Ting Qi, Diqiu Liu, Yaoxin Wang, Cheng Du*, Xiaojun Wang*. Development of a Test Card Based on Colloidal Gold Immunochromatographic Strips for Rapid Detection of Antibodies against Theileria equi and Babesia caballi. Microbiol Spectr. 2022 Feb 23;10(1): e0241121.
6. Kewei Chen, Zhe Hu, Guangpu Yang, Wei Guo, Ting Qi, Diqiu Liu, Yaoxin Wang, Cheng Du*, Xiaojun Wang*. Development of a duplex real-time PCR assay for simultaneous detection and differentiation of Theileria equi and Babesia caballi. Transbound Emerg Dis. 2022 Sep;69(5): e1338-e1349.
7. Guangpu Yang, Bingqian Zhou, Kewei Chen, Zhe Hu, Wei Guo, Xiaojun Wang*, Cheng Du*. Diagnostic Performance of Competitive ELISA and Western Blot Methods for the Detection of Antibodies against Theileria equi and Babesia caballi. Microorganisms. 2023 11,21:1-12.
8. Jinhui Wang, Kui Guo, Shuaijie, Diqiu Liu, Xiaoyu Chu, Yaoxin Wang, Wei Guo, Cheng Du*, Xiaojun Wang*, Zhe Hu*. Development and Application of Real-Time PCR Assay for Detection of Salmonella Abortusequi. J Clin Microbiol. 2023 Mar 23;61(3):e0137522.
9. Zhe Hu #, Kui Guo #, Cheng Du #, Jinhui Sun #, Ivancho Naletoski, Xiaoyu Chu, Yuezhi Lin, Xuefeng Wang, Maria Barrandeguy, Mi?o Samuel, Wen Wang, Patrick Imtung Lau, Ulrich Wernery, Rekha Raghavan, Xiaojun Wang*. Development and evaluation of a blocking ELISA for serological diagnosis of equine infectious anemia. Appl Microbiol Biotechnol. 2023 May;107(10):3305-3317.
10. Cheng Du，Zhe Hu，Sen-Dong Hu，Yue-Zhi Lin，Xiaojun Wang*，Yi-Jing Li*. Development and Application of an Indirect ELISA for the Detection of gp45 Antibodies to Equine Infectious Anemia Virus. Journal of Equine Veterinary ScienceVolume. 2018 Mar; 62: 76-80.
11. Cheng Du，Hai-Fang Liu，Yue-Zhi Lin，Xue-Feng Wang，Jian Ma，Yi-Jing Li，Xiaojun Wang*，Jian-Hua Zhou*. Proteomic alteration of equine monocyte-derived macrophages infected with equine infectious anemia virus. Proteomics, 201515(11):1843-1858.
12. Cheng Du，Jian Ma，Qiang Liu，Yun-Fei Li，Xi-Jun He，Yue-Zhi Lin，Xue-Feng Wang，Qing-Wen Meng*，Xiaojun Wang*，Jian-Hua Zhou* . Mice transgenic for equine cyclin T1 and ELR1 are susceptible to equine infectious anemia virus infection. Retrovirology. 2015, 12:36.
13. Cheng Du，Sandra Nilsson，Huijun Lu，Jigang Yin，Ning Jiang，Mats Wahlgren，Qijun Chen*. Immunogenicity of the Plasmodium falciparum Pf332-DBL domain in combination with different adjuvants. Vaccine. 2010, 28(31):4977-4983.
14. Qiang Liu, Xue-Feng Wang, Cheng Du, Yue-Zhi Lin, Jian Ma, Yu-Hong Wang, Jian-Hua Zhou*, Xiaojun Wang*. The integration of a macrophage-adapted live vaccine strain of equine infectious anaemia virus (EIAV) in the horse genome. J Gen Virol. 2017,Sep.
15. Yujie Wang, Haili Zhang, Lei Na, Cheng Du, Zhengyu Zhang, Xiaojun Wang*. ANP32A and ANP32B are key factors in the Rev-dependent CRM1 pathway for nuclear export of HIV-1 unspliced mRNA. J Biol Chem. 2019 Oct 18;294(42):15346-15357.
16. Haili Zhang, Zhengyu Zhang, Yujie Wang, Meiyue Wang, Xuefeng Wang, Xiang Zhang, Shuang Ji, Cheng Du, Hualan Chen, Xiaojun Wang. Fundamental Contribution and Host Range Determination of ANP32A and ANP32B in Influenza A Virus Polymerase Activity. J Virol. 2019 Jun 14;93(13): e00174-19.
17. Xue-Feng Wang, Shuai Wang, Qiang Liu, Yue-Zhi Lin, Cheng Du, Yan-Dong Tang, Lei Na, Xiaojun Wang*, Jian-Hua Zhou*. A unique evolution of the s2 gene of equine infectious anemia virus in hosts correlated with particular infection statuses. Viruses-Basel. 2014, 6(11): 4265-4279.
18. Xue-Feng Wang，Yue-Zhi Lin，Qiang Li，Qiang Liu，Wei-Wei Zhao，Cheng Du, Jie Chen, Xiaojun Wang*, Jian-Hua Zhou*. Genetic Evolution during the development of an attenuated EIAV vaccine. Retrovirology.2016, 13:9.
19. Yue-Zhi Lin，Liu-Ke Sun，Dan-Tong Zhu，Zhe Hu，Xue-Feng Wang，Cheng Du，Yu-Hong Wang，Xiao-Jun Wang*, Jian-Hua Zhou*. Equine schlafen 11 restricts the production of equine infectious anemia virus via a codon usage-dependent mechanism. Virology. 2016, 495:112-121.
20. Yue-Zhi Lin, Fei Yang, Shu-Qin Zhang, Liu-Ke Sun, Xue-Feng Wang, Cheng Du, Jian-Hua Zhou*. The Soluble Form of the EIAV Receptor Encoded by an Alternative Splicing Variant Inhibits EIAV Infection of Target Cells. PLos One. 2013, 8(11): e79299.
21. Jian Ma, Shan-Shan Wang, Yue-Zhi Lin, Hai-Fang Liu, Hua-Mian Wei, Cheng Du, Xue-Feng Wang, Jian-Hua Zhou*. An attenuated EIAV strain and its molecular clone strain differentially induce the expression of Toll-like receptors and type-I interferons in equine monocyte-derived macrophages. Veterinary Microbiology. 2013, 166(1-2): 263-269.
22. Qiang Liu, Jian Ma, Xue-Feng Wang, Fei Xiao, Li-Jia Li, Jiao-Er Zhang, Yue-Zhi Lin, Cheng Du, Xi-Jun He, Xiaojun Wang*, Jian-Hua Zhou*. Infection with equine infectious anemia virus vaccine strain EIAV(DLV121) causes no visible histopathological lesions in target organs in association with restricted viral replication and unique cytokine response. Veterinary Immunology and Immunopathology. 2016, 170: 30-40.
23. Jian Ma，Shan-Shan Wang，Yue-Zhi Lin，Hai-Fang Liu，Qiang Liu，Hua-Mian Wei，Xue-Feng Wang, Yu-Hong Wang, Cheng Du, Xian-Gang Kong, Jian-Hua Zhou*, Xiaojun Wang*. Infection of equine monocyte-derived macrophages with an attenuated equine infectious anemia virus (EIAV) strain induces a strong resistance to the infection by a virulent EIAV strain. Veterinary Research. 2014, 45:82.
專著：
1. 《馬傳染性貧血》，中國(guó)農(nóng)業(yè)出版社，2015，參編.
2. 《食品病原微生物》，中國(guó)輕工業(yè)出版社，2007，參編.
7、獲得獎(jiǎng)勵(lì)
1. 馬傳染性貧血弱毒疫苗致弱及免疫保護(hù)機(jī)制研究，中國(guó)農(nóng)業(yè)科學(xué)院杰出科技創(chuàng)新獎(jiǎng)，王曉鈞、林躍智、王雪峰、杜承、馬建、周建華、湯艷東、那雷、胡哲、劉強(qiáng)，2019年；
2. 馬傳染性貧血弱毒疫苗致弱及免疫保護(hù)機(jī)制研究，中國(guó)農(nóng)業(yè)科學(xué)院杰出科技創(chuàng)新獎(jiǎng)，王曉鈞、林躍智、王雪峰、杜承、馬建，2020年；
3. 惡性瘧原蟲(chóng)、日本血吸蟲(chóng)免疫逃避和致病的機(jī)理研究，吉林省科學(xué)技術(shù)獎(jiǎng)一等獎(jiǎng), 陳啟軍、姜寧、尹繼剛、陸慧君、王心蕊、常巧呈、杜承、張巖、武闖，2014年；
4. 微生物酶基因工程菌構(gòu)建及發(fā)酵特性研究，吉林省科學(xué)技術(shù)獎(jiǎng)三等獎(jiǎng), 孟憲梅、潘風(fēng)光、郭德軍、石彥忠、李鳳祥、孫肖明、杜承、秦亞楠，2012年；
5. 耐高溫淀粉酶的高效表達(dá)及生產(chǎn)新工藝研究，吉林省教育廳優(yōu)秀成果三等獎(jiǎng), 潘風(fēng)光、杜承、李金琦、王海修、孔海英、李鳳祥，2009年.
8、專利和標(biāo)準(zhǔn)
1. 姜寧、陳啟軍、杜承、尹繼剛、陸慧君，可抑制惡性瘧原蟲(chóng)侵入的抗Pf332-DBL區(qū)單克隆抗體，zl201210176879.6.
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