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1、個(gè)人簡(jiǎn)介
黨光輝，男，博士，副研究員，碩士生導(dǎo)師，中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所動(dòng)物細(xì)菌病創(chuàng)新團(tuán)隊(duì)成員，中國(guó)防癆協(xié)會(huì)人獸共患結(jié)核病專業(yè)分會(huì)委員。主持十四五國(guó)家重點(diǎn)研發(fā)計(jì)劃子課題、國(guó)家自然科學(xué)基金等項(xiàng)目3項(xiàng)。以第一（含共第一）和通訊作者發(fā)表文章16篇，獲得授權(quán)發(fā)明專利2項(xiàng)。協(xié)助培養(yǎng)研究生12名。目前主要從事結(jié)核病和副結(jié)核病致病機(jī)制研究、亞單位疫苗和診斷制品的開(kāi)發(fā)。
2、聯(lián)系方式
研究方向：獸醫(yī)微生物及其分子生物學(xué)
電話：0451-51051732
郵箱：dangguanghui@caas.cn
通訊地址：黑龍江省哈爾濱市香坊區(qū)哈平路678號(hào)綜合樓5008，150069
3、教育經(jīng)歷
2004.09-2009.06 河南科技學(xué)院 動(dòng)物醫(yī)學(xué) 學(xué)士
2010.09-2012.06 福建農(nóng)林大學(xué) 基礎(chǔ)獸醫(yī)學(xué) 碩士
2014.09-2018.01 中國(guó)農(nóng)業(yè)科學(xué)院研究生院 預(yù)防獸醫(yī)學(xué) 博士
4、工作經(jīng)歷
2013.07-2014.08 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 科研助理
2018.11-2023.07 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 博士后
2022.01-至今 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 副研究員
5、 承擔(dān)的項(xiàng)目
國(guó)家自然科學(xué)基金青年項(xiàng)目，32002256，Rv3194c蛋白酶在結(jié)核分枝桿菌逃逸IgG介導(dǎo)的免疫殺傷中的作用機(jī)制研究，2021-01-01 至 2023-12-31，24萬(wàn)元， 主持
“十四五”國(guó)家重點(diǎn)研發(fā)計(jì)劃子課題，2023YFD1801302，“瀕危和青藏高原動(dòng)物結(jié)核病和副結(jié)核病診斷技術(shù)與產(chǎn)品研發(fā)”2023-12-01至2027-12-31，60萬(wàn)元，主持
中央級(jí)公益性科研院所基本科研業(yè)務(wù)費(fèi)項(xiàng)目，1610302024002，XthA磷脂酶影響分枝桿菌分枝菌酸合成的機(jī)制研究，2024-01-01至2024-12-31，16萬(wàn)元，主持
國(guó)家自然科學(xué)基金面上項(xiàng)目，32273005，結(jié)核分枝桿菌Rv2569c半胱氨酸蛋白酶介導(dǎo)的Caspase非依賴性巨噬細(xì)胞凋亡的機(jī)制研究，2023-01-01至2026-12-31，54萬(wàn)元，參與
6、代表論文與著作
Zang Xinxin, Zhang Jiajun, Jiang Yanyan, Feng Tingting, Cui Yingying, Wang Hui, Cui Ziyin, Dang Guanghui*, Liu Siguo*. Serine protease Rv2569c facilitates transmission of Mycobacterium tuberculosis via disrupting the epithelial barrier by cleaving E-cadherin. PLoS Pathogens, 2024 20(5): e1012214.
Shao Mingzhu, Cui Ning, Tang Yangyang, Chen Fanruo, Cui Yingying, Dang Guanghui*, Liu Siguo*. A candidate subunit vaccine induces protective immunity against Mycobacterium avium subspecies paratuberculosis in mice. NPJ Vaccines. 2023 8(1):72.
Zhang Jiajun, Cui Yingying, Zang Xinxin, Feng Tingting, Chen Fanruo, Wang Hui, Dang Guanghui*, Liu Siguo*. PE12 interaction with TLR4 promotes intracellular survival of Mycobacterium tuberculosis by suppressing inflammatory response. International Journal of Biological Macromolecules. 2023 253(Pt 8):127547.
Tang Yangyang, Cui Yingying, Jiang Yanyan, Shao Mingzhu, Zang Xinxin, Dang Guanghui*, Liu Siguo*. Characteristics of Mycobacterium tuberculosis serine protease Rv1043c in enzymology and pathogenicity in mice. Journal of Integrative Agriculture. 2023 22(12):3755-3768.
Zang Xinxin#, Dang Guanghui#, Cai Zhuming, Shao Mingzhu, Tang Yangyang, Cao Jun, Cui Ziyin, Liu Siguo*. (2022). Extracellular DNase MAP3916c attacks the neutrophil extracellular traps and is needed for Mycobacterium avium subsp. paratuberculosis virulence. Veterinary microbiology. 2022, 273, 109529.
Cui Yingying#, Tang Yangyang#, Shao Mingzhu, Zang Xinxin, Jiang Yanyan, Cui Ziyin, Dang Guanghui*, Liu Siguo*. Mycobacterium tuberculosis protease Rv3090 is associated with late cell apoptosis and participates in organ injuries and mycobacterial dissemination in mice. Microbial pathogenesis, 2022, 173(Pt B), 105880.
Liu Hongxiu#, Dang Guanghui#, Zang Xinxin, Cai Zhuming, Song Ningning, Liu Siguo*. Characterization and pathogenicity of extracellular serine protease MAP3292c from Mycobacterium avium subsp. paratuberculosis. Microbial Pathogenesis. 2020, 142: 104055.
Li He#, Dang Guanghui#, Liu Hongxiu, Wang Zhongxing, Cui Ziyin, Song Ningning, Chen Liping, Liu Siguo. Characterization of a novel Mycobacterium tuberculosis serine protease (Rv3194c) activity and pathogenicity. Tuberculosis. 2019, 119:101880.
Dang Guanghui, Cui Yingying, Wang Lei, Li Tiantian, Cui Ziyin, Song Ningning, Chen Liping, Pang Hai, Liu Siguo*. Extracellular Sphingomyelinase Rv0888 of Mycobacterium tuberculosis Contributes to Pathological Lung Injury of Mycobacterium smegmatis in Mice via Inducing Formation of Neutrophil Extracellular Traps. Frontiers in immunology. 2018, 9:677.
Dang Guanghui, Cao Jun, Cui Yingying, Song Ningning, Chen Liping*, Pang Hai*, Liu Siguo*. Characterization of Rv0888, a Novel Extracellular Nuclease from Mycobacterium tuberculosis. Scientific Reports. 2016, 6:19033.
Dang Guanghui#, Chen Liping#, Li Zhaoli, Deng Xiaoxia, Cui Yingying, Cao Jun, Yu Shenye, Pang Hai*, Liu Siguo*. Expression, Purification and Characterisation of Secreted Esterase Rv2525c from Mycobacterium tuberculosis. Applied Biochemistry and Biotechnology. 2015, 176(1): 1-12.
Chen Liping#, Dang Guanghui#, Deng Xiaoxia, Cao Jun, Yu Shenye, Wu Defeng, Pang Hai*, Liu Siguo*. Characterization of a novel exported esterase Rv3036c from Mycobacterium tuberculosis. Protein Expression and Purification. 2014, 104: 50-56.
陳凡若, 張嘉俊, 鹿萍, 崔寧, 崔瑩瑩, 崔子寅, 黨光輝*, 劉思國(guó)*. 副結(jié)核分枝桿菌免疫原蛋白的篩選及免疫保護(hù)效果評(píng)價(jià)[J]. 中國(guó)農(nóng)業(yè)科學(xué), 2024, 57 (06): 1204-1214.
蔡珠明#, 黨光輝#, 臧鑫鑫, 邵明珠, 唐陽(yáng)陽(yáng), 鹿萍, 崔瑩瑩, 崔子寅, 劉思國(guó). 結(jié)核分枝桿菌復(fù)合群、副結(jié)核分枝桿菌和禽分枝桿菌禽亞種多重TaqMan熒光定量PCR方法的建立及初步應(yīng)用[J]. 中國(guó)預(yù)防獸醫(yī)學(xué)報(bào), 2023, 45 (01): 51-59.
陳凡若#, 黨光輝#, 張嘉俊, 鹿萍, 崔寧, 崔瑩瑩, 崔子寅, 劉思國(guó). 結(jié)核分枝桿菌PE26蛋白調(diào)節(jié)巨噬細(xì)胞免疫反應(yīng)進(jìn)而促進(jìn)分枝桿菌胞內(nèi)定殖[J]. 中國(guó)預(yù)防獸醫(yī)學(xué)報(bào), 2023, 45 (05): 502-509.
臧鑫鑫#，黨光輝#，王忠星，劉虹秀，崔子寅，崔瑩瑩，宋寧寧，劉思國(guó). 恥垢分支桿菌能夠誘導(dǎo)中性粒細(xì)胞胞外誘捕網(wǎng)的形成. 中國(guó)預(yù)防獸醫(yī)學(xué)報(bào). 2019, 41(11): 1154-1158.
7、專利
黨光輝，劉思國(guó)，蔡珠明，崔子寅. 一種同時(shí)檢測(cè)三種分枝桿菌的多重TaqMan熒光定量PCR試劑盒及其應(yīng)用. 專利號(hào)：ZL202110731289.4
劉思國(guó)，黨光輝，陳利蘋(píng)，李田田. 一種牛副結(jié)核間接ELISA檢測(cè)試劑盒及其應(yīng)用. 專利號(hào)：ZL202310215284.5
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