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1、個人簡歷

姜麗，女，博士，中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所動物流感基礎(chǔ)與防控研究創(chuàng)新團隊，研究員。2007年畢業(yè)于中國科學(xué)院遺傳與發(fā)育生物學(xué)研究所并獲得理學(xué)博士學(xué)位，自2008年起在美國威斯康星大學(xué)麥迪遜主校區(qū)醫(yī)學(xué)院從事重要疾病相關(guān)的生物大分子結(jié)構(gòu)與功能研究。2012年加入中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所動物流感基礎(chǔ)與防控研究團隊，主要從事流感病毒與宿主互作的相關(guān)基礎(chǔ)研究工作。

2、聯(lián)系方式

電話：0451-51051759

郵箱：jiangli@caas.cn

通訊地址：黑龍江省哈爾濱市香坊區(qū)哈平路678號

3、工作經(jīng)歷

2019.1-今  中國農(nóng)科院哈爾濱獸醫(yī)研究所  研究員

2012.11-2018.12  中國農(nóng)科院哈爾濱獸醫(yī)研究所  副研究員

2008.05-2012.10  威斯康星大學(xué)醫(yī)學(xué)院  研究助理及博士后

4、承擔(dān)主要科研項目

1. 科技部十四五重點研發(fā)計劃項目，2024YFE0198700，新發(fā)禽流感病毒跨種感染和致病機制研究，2024/9-2027/8，377.55萬元，主持

2. 黑龍江省自然科學(xué)基金杰青項目，JQ2023C006，流感病毒核糖核蛋白復(fù)合體VRNP與宿主互作研究，2023/7-2026/7，50萬元，主持

3. 國家自然科學(xué)基金面上項目，32172847，宿主蛋白ABTB1調(diào)控流感病毒復(fù)制的分子機理，2022/1-2025/12，58萬元，主持

4. 國家自然科學(xué)基金面上項目，31672582，宿主蛋白與流感病毒NP蛋白互作及調(diào)控病毒復(fù)制機制研究，2017/1-2020/12，61萬元，主持

5. 國家自然科學(xué)基金創(chuàng)新研究群體科學(xué)基金，31521005，動物傳染病，2016/1-2021/12，1200萬元， 參與

5、代表性研究論文   

1. Guangwen Wang, Li Jiang, Jinliang Wang, Qibing Li, Jie Zhang, Fandi Kong, Ya Yan, Yuqin Wang, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Liling Liu, Zhigao Bu, Hualan Chen, Chengjun Li. Genome-wide siRNA library screening identifies human host factors that influence the replication of the highly pathogenic H5N1 influenza virus. mLife. 2025 Feb 24;4(1):55-69. doi: 10.1002/mlf2.12168.

2. Yuzhen Hu, Li Jiang, Guangwen Wang, Yangming Song, Zhibo Shan, Xuyuan Wang, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Liling Liu, Hualan Chen, Chengjun Li. M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes. Sci China Life Sci. 2024 Mar;67(3):579-595. doi: 10.1007/s11427-023-2471-4.  

3. Wenjun Shi , Zhibo Shan , Li Jiang , Guangwen Wang, Xuyuan Wang, Yu Chang, Yuzhen Hu, Bo Wang, Qibing Li, Yihan Wang, Guohua Deng, Jianzhong Shi, Yongping Jiang, Xianying Zeng, Guobin Tian, Hualan Chen, Chengjun Li. ABTB1 facilitates the replication of influenza A virus by counteracting TRIM4-mediated degradation of viral NP protein. Emerg Microbes Infect. 2023 Dec;12(2):2270073. doi: 10.1080/22221751.2023.2270073.  Epub 2023 Nov 2.

4. Li Jiang, Hualan Chen, Chengjun Li. Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins. Cell Insight. 2023 Jan 31;2(2):100079. doi: 10.1016/j.cellin.2023.100079.

5. Junping Li, Libin Liang, Li Jiang, Qian Wang, Xia Wen, Yuhui Zhao, Pengfei Cui, Yaping Zhang, Guangwen Wang, Qibing Li, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Yongping Jiang, Liling Liu, Hualan Chen, Chengjun Li. Viral RNA-binding ability conferred by SUMOylation at PB1 K612 of influenza A virus is essential for viral pathogenesis and transmission PLoS Pathog. . 2021 Feb 11;17(2):e1009336. doi: 10.1371/journal.ppat.1009336.

6. Nan Sun, Li Jiang, Miaomiao Ye, Yihan Wang, Guangwen Wang, Xiaopeng Wan, Yuhui Zhao, Xia Wen, Libin Liang, Shujie Ma, Liling Liu, Zhigao Bu, Hualan Chen, Chengjun Li. TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2. Protein Cell. 2020 Dec;11(12):894-914. doi: 10.1007/s13238-020-00734-6.

7. Libin Liang, Li Jiang, Junping Li, Qingqing Zhao, Jinguang Wang, Xijun He, Shanyu Huang, Qian Wang, Yuhui Zhao, Guangwen Wang, Nan Sun, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Yongping Jiang, Liling Liu, Jinxiong Liu, Pucheng Chen, Zhigao Bu, Yoshihiro Kawaoka, Hualan Chen, Chengjun Li. Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals. mBio. 2019 Jun 18;10(3):e01162-19. doi: 10.1128/mBio.01162-19.

8. Weiyu Luo, Jie Zhang, Libin Liang, Guangwen Wang, Qibing Li, Pengyang Zhu, Yuan Zhou, Junping Li, Yuhui Zhao, Nan Sun, Shanyu Huang, Chenchen Zhou, Yu Chang, Pengfei Cui, Pucheng Chen, Yongping Jiang, Guohua Deng, Zhigao Bu, Chengjun Li, Li Jiang, Hualan Chen. Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication. PLoS Pathog. 2018 Jan 19;14(1):e1006851. doi: 10.1371/journal.ppat.1006851.

9. Seung-Hyeon Seok, Woojong Lee, Li Jiang, Kaivalya Molugu, Aiping Zheng, Yitong Li, Sanghyun Park, Christopher A Bradfield, Yongna Xing. Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex. Proc Natl Acad Sci U S A. 2017 May 23;114(21):5431-5436. doi: 10.1073/pnas.1617035114.  Epub 2017 Apr 10.

10. Li Jiang, Vitali Stanevich, Kenneth A Satyshur, Mei Kong, Guy R Watkins, Brian E Wadzinski, Rituparna Sengupta, Yongna Xing. Structural basis of protein phosphatase 2A stable latency. Nat Commun. 2013:4:1699. doi: 10.1038/ncomms2663.