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1、個(gè)人簡(jiǎn)歷
鄧國(guó)華，男，博士，三級(jí)研究員，博士生導(dǎo)師，動(dòng)物流感防控與基礎(chǔ)研究創(chuàng)新團(tuán)隊(duì)骨干一級(jí)，從事禽流感監(jiān)測(cè)與流行病學(xué)研究工作，多年來(lái)一直主持、承擔(dān)和參與多項(xiàng)禽流感病毒基礎(chǔ)研究以及應(yīng)用基礎(chǔ)研究項(xiàng)目，包括國(guó)家973項(xiàng)目、國(guó)家科技支撐項(xiàng)目、國(guó)家重點(diǎn)研發(fā)計(jì)劃和國(guó)家自然科學(xué)基金項(xiàng)目等，發(fā)表SCI及中文核心期刊論文100余篇。先后獲得國(guó)家科技進(jìn)步一等獎(jiǎng)、國(guó)家技術(shù)發(fā)明二等獎(jiǎng)、國(guó)家自然科學(xué)獎(jiǎng)二等獎(jiǎng)、黑龍江省自然科學(xué)一等獎(jiǎng)、科技進(jìn)步一等獎(jiǎng)、哈爾濱市科技進(jìn)步獎(jiǎng)二等獎(jiǎng)、黑龍江省青年“五四”獎(jiǎng)?wù)碌泉?jiǎng)勵(lì)和榮譽(yù)。目前兼任揚(yáng)州大學(xué)客座教授和兼職碩士研究生導(dǎo)師，中國(guó)畜牧獸醫(yī)學(xué)會(huì)禽病學(xué)分會(huì)理事，第六屆農(nóng)業(yè)轉(zhuǎn)基因生物安全委員會(huì)委員，第四屆全國(guó)動(dòng)物防疫專家委員會(huì)委員。
2、聯(lián)系方式
研究方向：動(dòng)物傳染病及其病原分子流行病學(xué)
聯(lián)系電話：0451-51051806
郵箱：dengguohua01@caas.cn
通訊地址：哈爾濱市香坊區(qū)哈平路678號(hào)
3、教育經(jīng)歷
1990/09-1995/06 華中農(nóng)業(yè)大學(xué) 獸醫(yī)專業(yè) 學(xué)士
1999/09-2001/03 東北農(nóng)業(yè)大學(xué) 預(yù)防獸醫(yī)學(xué)專業(yè) 碩士
2001/09-2004/06 中國(guó)農(nóng)業(yè)大學(xué) 預(yù)防獸醫(yī)學(xué)專業(yè) 博士
4、工作經(jīng)歷
1995/07-1999/12 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 研究實(shí)習(xí)員
2000/01-2004/12 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 助理研究員
2005/01-2011/12 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 副研究員
2007/03-2008/03 英國(guó)牛津大學(xué) 訪問(wèn)學(xué)者
2012/01-今 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 研究員
5、承擔(dān)的課題
1. 國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目課題“動(dòng)物流感病毒監(jiān)測(cè)及進(jìn)化研究”，2021YFD1800201,2021.05-2025.12,1145萬(wàn)，課題負(fù)責(zé)人；
2. 國(guó)家自然科學(xué)基金面上項(xiàng)目“2.3.4.4分支H5亞型禽流感病毒抗原差異的分子基礎(chǔ)”，32172837，2022.01-2025.12,58萬(wàn)，項(xiàng)目負(fù)責(zé)人；
3. 農(nóng)業(yè)農(nóng)村部行業(yè)專項(xiàng)“奶牛禽流感病毒感染及禽流感防治措施評(píng)估”，“禽流感病毒遺傳進(jìn)化”，每年148.24萬(wàn)，項(xiàng)目負(fù)責(zé)人；
4. 國(guó)家自然科學(xué)基金地區(qū)聯(lián)合基金項(xiàng)目“西北地區(qū)禽流感病毒生態(tài)分布及其傳播機(jī)制研究”，U23A20243，103.2萬(wàn)，項(xiàng)目參與人。
6、代表論文與著作
1. Yan C#, Shi J#, Cui P#, Chen Y, Wang C, Wang Y, Miao J, Zhang Y, Kong H, Zeng X, Tian G, Li C, Suzuki Y, Deng G.*, Chen H.* 2025. Characterization of emerging H3N3 avian influenza viruses in poultry in China. Emerg Microbes Infect 14:2509748.
2. Cui P. #, Shi J. #, Yan C. #, Wang C, Zhang Y, Zhang Y, Xing X, Chen Y, Zhang J, Liu L, Zeng X, Tian G, Li C, Suzuki Y, Deng G.*, Chen H.* 2023. Analysis of avian influenza A (H3N8) viruses in poultry and their zoonotic potential, China, September 2021 to May 2022. Euro Surveill: 2023 Oct;28(41):2200871. doi: 10.2807/1560-7917.ES.2023.28.41.2200871.
3. Hou Y.*, Deng G.*, Cui P., Zeng X., Li B., Wang D., He X., Yan C., Zhang Y., Li J., Ma J., Li Y., Wang X., Tian G., Kong H., Tang l., Yasuo Suzuki, Shi J. *, Chen H. *, Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccination. Emerg Microbes Infect. 2024 Dec;13(1):2343912. doi: 10.1080/22221751.2024.2343912.
4. Xing X., Shi J., Cui P., Yan C., Zhang Y., Zhang Y., Wang C., Chen Y., Zeng X., Tian G., Liu L., Guan Y., Li C., Yasuo Suzuki, Deng G.*, Chen H.*, Evolution and biological characterization of H5N1 influenza viruses bearing the clade 2.3.2.1 hemagglutinin gene. Emerg Microbes Infect. 2024 Dec;13(1):2284294. doi: 10.1080/22221751.2023.2284294.
5. Zhang Y., Shi J., Cui P., Zhang Y., Chen Y., Hou Y., Liu L., Jiang Y., Guan Y., Chen H., Kong H.*, Deng G.*, Genetic analysis and biological characterization of H10N3 influenza A viruses isolated in China from 2014 to 2021. J Med Virol. 2023 Feb;95(2):e28476. doi: 10.1002/jmv.28476.
6. Zhang Y., Cui P., Shi J., Chen Y., Zeng X., Jiang Y., Tian G., Li C., Chen H., Kong H.*, Deng G.*, Key Amino Acid Residues That Determine the Antigenic Properties of Highly Pathogenic H5 Influenza Viruses Bearing the Clade 2.3.4.4 Hemagglutinin Gene. Viruses. 2023 Nov 13;15(11):2249. doi: 10.3390/v15112249.
7. Zhang Y., Cui P., Shi J., Zeng X., Jiang Y., Chen Y., Zhang J., Wang C., Wang Y., Tian G., Chen H., Kong H.*, Deng G.*, A broad-spectrum vaccine candidate against H5 viruses bearing different sub-clade 2.3.4.4 HA genes. NPJ Vaccines. 2024 Aug 19;9(1):152. doi: 10.1038/s41541-024-00947-4.
8. Gu W.#, Shi J.#, Cui P.#, Yan C., Zhang y., Wang C., Zhang Y., Xing X., Zeng X., Liu L., Tian G., Yasuo Suzuki, Li C., Deng G.*, Chen H.*. Novel H5N6 reassortants bearing the clade 2.3.4.4b HA gene of H5N8 virus have been detected in poultry and caused multiple human infections in China. Emerg Microbes Infect. 2022 Dec;11(1):1174-1185. doi: 10.1080 /22221751. 2022.2063076.
9. Cui P.#, Shi J,.#, Wang C.#, Zhang Y., Xing X., Kong H., Yan C., Zeng X., Liu L., Tian G., Li C., Deng G.*, Chen H.*. Global dissemination of H5N1 influenza viruses bearing the clade 2.3.4.4b HA gene and biologic analysis of the ones detected in China. Emerg Microbes Infect. 2022 Dec;11(1):1693-1704. doi: 10.1080/22221751.2022.2088407.
10. Cui P. #, Zeng X. #, Li X. #, Li Y. #, Shi J. #, Zhao C, Qu Z, Wang Y, Guo J, Gu W, Ma Q, Zhang Y, Lin W, Li M, Tian J, Wang D, Xing X, Liu Y, Pan S, Zhang Y, Bao H, Liu L, Tian G, Li C, Deng G*, Chen H*. Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China. Sci China Life Sci. 2021 Nov 8. doi: 10.1007/s11427-021-2025-y.
11. Cui J., Cui P., Shi J., Fan w, Xing X., Gu W., Zhang Y., Zhang Y., Zeng X., Jiang Y., Chen P., Yang H., Chen Y., Liu J., Liu L., Tian G, Lu Y., Chen H, Li C. *, Deng G. *. Continued evolution of H6 avian influenza viruses isolated from farms in China between 2014 and 2018, Transboundary and Emerging Diseases. First published: 30 June 2021, https://doi.org/10.1111/tbed.14212.
12. Kong X., Guan L., Shi J., Kong H., Zhang Y., Zeng X., Tian G., Liu L., Li C., Yoshihiro Kawaoka, Deng G. *, Chen H. *. A single-amino-acid mutation at position 225 in hemagglutinin attenuates H5N6 influenza virus in mice. Emerg Microbes Infect. 2021 Dec; 10(1): 2052-2061. doi: 10.1080/22221751.2021.1997340.
13. Yin X.#, Deng G.#, Zeng X.#, Cui P., Hou Y. , Liu Y., Fang J., Pan S., Wang D., Chen X., Zhang Y., Wang X., Tian G., Li Y., Chen Y., Liu L., Yasuo Suzuki, Guan Y., Li C., Shi J. *, Chen H. *. Genetic and biological properties of H7N9 avian influenza viruses detected after application of the H7N9 poultry vaccine in China. PLoS Pathog. 2021 Apr 27;17(4):e1009561. doi: 10.1371/journal.ppat.1009561.
14. Guan L., Shi J., Kong X., Ma S., Zhang Y., Yin X., He X., Liu L., Suzuki Y., Li C., Deng G.*, Chen H.*. H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets. Emerg Microbes Infect. 2019;8(1):1280-1290. doi: 10.1080/22221751.2019.1660590.
15. Li X, Cui P, Zeng X, Jiang Y, Li Y, Yang J, Pan Y, Gao X, Zhao C, Wang J, Wang K, Deng G*, Guo J*. Characterization of avian influenza H5N3 reassortants isolated from migratory waterfowl and domestic ducks in China from 2015 to 2018. Transbound Emerg Dis. 2019 Nov; 66(6):2605-2610. doi: 10.1111/tbed.13324. Epub 2019Aug 26.
16. Shi J. #, Deng G. #, Ma S., Zeng X., Yin X., Li M., Zhang B., Cui P., Chen Y., Yang H., Wan X., Liu l., Chen P., Jiang Y., Guan Y., Liu J., Gu W., Han S., Chen H.. Rapid Evolution of H7N9 Highly Pathogenic Viruses that Emerged in China in 2017. Cell Host &Microbe. 2018, Volume 24, Issue 4, 10 October, Pages 558-568.e7.
17. Shi J. #, Deng G. #, Kong H., Gu C., Ma S., Yin X., Zeng X, Cui P, Chen Y, Yang H, Wan X, Wang X, Liu L, Chen P, Jiang Y, Liu J, Guan Y, Suzuki Y, Li M, Qu Z, Guan L, Zang J, Gu W, Han S, Song Y, Hu Y, Wang Z, Gu L, Yang W, Liang L, Bao H, Tian G, Li Y, Qiao C, Jiang L, Li C, Bu Z, Chen H*. H7N9 virulent mutants detected in chickens in China pose an increased threat to humans. Cell Research. 2017 Dec;27(12):1409-1421. doi: 10.1038/cr.2017.
18. Cui P, Deng G*, Shi J, Kong H, Liu L, Guan Y, Suzuki Y, Chen H*. 2016. New influenza A(H7N7) viruses detected in live poultry markets in China. Virology. 2016, 499:165-169.
19. Liang L. #, Deng G. #, Shi J., Wang S., Zhang Q., Kong H., Gu C., Guan Y., Suzuki Y., Li Y., Jiang Y., Tian G., Liu L., Li C.*, Chen H.*. Genetics, Receptor Binding, Replication, and Mammalian Transmission of H4 Avian Influenza Viruses Isolated from Live Poultry Markets in China. Journal of Virology. 2015.90:1455-1469.
20. Deng G.#, Shi J. #, Wang J., Kong H., Cui P., Zhang F., Tan D., Suzuki Y., Liu L., Jiang Y., Guan Y., Chen H*. Genetics, Receptor Binding, and Virulence in Mice of H10N8 Influenza Viruses Isolated from Ducks and Chickens in Live Poultry Markets in China. Journal of Virology. 2015. 89:6506-6510.
21. Shi J., Deng G., Zeng X., Kong H., Wang X., Lu K., Wang X., Mu G., Xu X., Cui P., Bao H., Tian G., Chen H*. Novel influenza A(H7N2) virus in chickens, Jilin province, China, 2014. Emerging Infectious Disease. 2014. 20:1719-1722.
22. Wang G. #, Deng G. #, Shi J., Luo W., Zhang G., Zhang Q., Liu L., Jiang Y., Li C., Sriwilaijaroen N., Hiramatsu H., Suzuki Y., Kawaoka Y., Chen H*. H6 influenza viruses pose a potential threat to human health. Journal of Virology. 2014. 88:3953-3964.
23. Zhang Q. #, Shi J. #, Deng G. #, Guo J. #, Zeng X. #, He X., Kong H., Gu C., Li X., Liu J., Wang G., Chen Y., Liu L., Liang L., Li Y., Fan J., Wang J., Li W., Guan L., Li Q., Yang H., Chen P., Jiang L., Guan Y., Xin X., Jiang Y., Tian G., Wang X., Qiao C., Li C., Bu Z., Chen H*. H7N9 influenza viruses are transmissible in ferrets by respiratory droplet. Science. 2013. 341:410-414.
24. Deng G. #, Tan D. #, Shi J., Cui P., Jiang Y., Liu L., Tian G., Kawaoka Y., Li C.*, Chen H.*. Complex reassortment of multiple subtypes of avian influenza viruses in domestic ducks at the dongting lake region of china. Journal of Virology. 2013. 87:9452-9462.
25. Ge J., Deng G., Wen Z., Tian G., Wang Y., Shi J., Wang X., Li Y., Hu S., Jiang Y., Yang C., Yu K., Bu Z.*, Chen H.*. Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses. Journal of Virology. 2007. 81:150-158.
26. Chen H*, Deng G., Li Z., Tian G., Li Y., Jiao P., Zhang L., Liu Z., Webster RG., Yu K. The evolution of H5N1 influenza viruses in ducks in Southern China. Proc. Natl. Acad. Sci. USA. 2004.101:10452-10457.
8、專利
1. H5-Re11血凝素蛋白單克隆抗體及其抗原表位的應(yīng)用，ZL 2024 1 0768077.7，鄧國(guó)華，崔鵬飛，陳化蘭，孔暉暉，施建忠，王秀榮;
2. 一種廣譜性識(shí)別N9亞型禽流感病毒神經(jīng)氨酸酶蛋白的單克隆抗體及其應(yīng)用，中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所，授權(quán)， 2020100645011，鄧國(guó)華，崔鵬飛，陳化蘭，施建忠；
3. 一種識(shí)別N6亞型禽流感病毒神經(jīng)氨酸酶蛋白的單克隆抗體及其應(yīng)用，中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所，授權(quán)，2020100667951， 鄧國(guó)華，崔鵬飛，陳化蘭，施建忠。
9、獲得獎(jiǎng)勵(lì)
1. 流感病毒跨種感染人及傳播能力研究，國(guó)家自然科學(xué)獎(jiǎng)二等獎(jiǎng)，陳化蘭，施建忠，鄧國(guó)華，楊煥良，李雁冰，2019年12月18日；
2. 動(dòng)物流感病毒跨種傳播能力研究，黑龍江省自然科學(xué)獎(jiǎng)一等獎(jiǎng)，陳化蘭，施建忠，鄧國(guó)華，楊煥良，李雁冰，2018年;
3. 動(dòng)物流感病毒引起人流感大流行的潛力及其遺傳機(jī)制，中國(guó)農(nóng)業(yè)科學(xué)院杰出科技創(chuàng)新獎(jiǎng)，陳化蘭、施建忠、鄧國(guó)華、李雁冰、李呈軍、曾顯營(yíng)、劉麗玲、姜永萍、何希君、田國(guó)彬、關(guān)云濤、柳金雄、陳普成、陳艷、楊煥良，2015年;
4. 禽流感病毒進(jìn)化、跨種感染及致病力分子機(jī)制研究，國(guó)家自然科學(xué)獎(jiǎng)二等獎(jiǎng)，陳化蘭，于康震，鄧國(guó)華，周繼勇，李澤軍，2013年;
5. H5N1亞型禽流感病毒進(jìn)化、跨宿主感染及致病力分子機(jī)制研究，黑龍江省自然科學(xué)獎(jiǎng)一等獎(jiǎng)，陳化蘭、鄧國(guó)華、李雁冰、姜永萍、田國(guó)彬，2009年;
6. 禽流感、新城疫重組二聯(lián)活疫苗，國(guó)家技術(shù)發(fā)明獎(jiǎng)二等獎(jiǎng)，陳化蘭，步志高，葛金英，田國(guó)彬，李雁冰，鄧國(guó)華；2007年；H5亞型禽流感滅活疫苗的研制與應(yīng)用，國(guó)家科學(xué)技術(shù)進(jìn)步一等獎(jiǎng)，于康震、陳化蘭、田國(guó)彬、辛朝安、唐秀英、廖明、張?zhí)K華、李雁冰、馮菊艷、李曉成、羅開健、施建忠、喬傳玲、姜永萍、鄧國(guó)華，2005年；
7. 于康震禽流感病毒重組核蛋白瓊擴(kuò)抗原的研制與應(yīng)用，黑龍江省科學(xué)技術(shù)進(jìn)步一等獎(jiǎng)，王秀榮、鄧國(guó)華、陳化蘭、楊林、田國(guó)彬、郭昭林、姜永萍、喬傳玲、孫建宏，2004年。
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