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1、個(gè)人簡(jiǎn)歷
李呈軍，男，中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所研究員，博士生導(dǎo)師，動(dòng)物流感基礎(chǔ)與防控研究創(chuàng)新團(tuán)隊(duì)助理首席。2014年獲得國(guó)家自然科學(xué)基金“優(yōu)秀青年科學(xué)基金”資助，2016年入選科技部創(chuàng)新人才推進(jìn)計(jì)劃“中青年科技創(chuàng)新領(lǐng)軍人才”和中國(guó)農(nóng)業(yè)科學(xué)院“科研英才培育工程”，2017年入選中國(guó)農(nóng)業(yè)科學(xué)院“農(nóng)科英才”B類人才。兼任獸醫(yī)生物技術(shù)國(guó)家重點(diǎn)實(shí)驗(yàn)室副主任、中國(guó)微生物學(xué)會(huì)病毒學(xué)專業(yè)委員會(huì)委員、中國(guó)畜牧獸醫(yī)學(xué)會(huì)理事和Virology Journal期刊流感欄目副主編。2000年以來，一直專注于流感病毒的基礎(chǔ)和防控研究，以第一或通訊作者在Nature Microbiology，PNAS，Protein & Cell，PLoS Pathogens，mBio，Journal of Virology等雜志發(fā)表SCI論文20多篇。主持國(guó)家自然科學(xué)基金優(yōu)青項(xiàng)目、重大項(xiàng)目課題、面上項(xiàng)目、黑龍江省杰青項(xiàng)目，是國(guó)家自然科學(xué)基金創(chuàng)新研究群體項(xiàng)目、“十三五”和“十四五”國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目及黑龍江省獸醫(yī)病毒學(xué)創(chuàng)新研究“頭雁”團(tuán)隊(duì)學(xué)術(shù)骨干。
2、聯(lián)系方式
電話：0451-51051688
電子郵箱：lichengjun@caas.cn
通訊地址：哈爾濱市香坊區(qū)哈平路678號(hào)
3、教育經(jīng)歷
1996.09–2000.06 河北農(nóng)業(yè)大學(xué) 獸醫(yī)專業(yè) 學(xué)士
2000.09–2005.06 中國(guó)農(nóng)業(yè)科學(xué)院研究生院 預(yù)防獸醫(yī)學(xué)專業(yè) 博士
4、工作經(jīng)歷
2005.07–2005.09 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 助理研究員
2005.10–2010.04 美國(guó)威斯康星-麥迪遜大學(xué) 博士后
2010.05–2012.10 美國(guó)威斯康星-麥迪遜大學(xué) 助理科學(xué)家
2012.10–至今 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 研究員
2019.09–2022.06 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 科研管理與國(guó)際合作處處長(zhǎng)
2022.06–至今 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 獸醫(yī)生物技術(shù)國(guó)家重點(diǎn)實(shí)驗(yàn)室副主任
5、承擔(dān)主要科研項(xiàng)目（不超過10項(xiàng) ）
國(guó)家自然科學(xué)基金重大項(xiàng)目課題：潛在流行風(fēng)險(xiǎn)動(dòng)物源性人獸共患病毒致病及跨種傳播機(jī)制（32192453），2022.01-2026.12，284.8萬元，主持。
嶺南現(xiàn)代農(nóng)業(yè)科學(xué)與技術(shù)廣東省實(shí)驗(yàn)室科研項(xiàng)目：新發(fā)/突發(fā)畜禽動(dòng)物疫病的阻斷技術(shù)研究（NT2021007），2021.10-2024.09，1500萬元，子課題主持。
國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目：動(dòng)物流感病毒的流行規(guī)律與傳播機(jī)制研究（2021YFD1800200），2021.05-2025.12，5500萬元，參加。
黑龍江省杰出青年科學(xué)基金：TRIM家族蛋白調(diào)控流感病毒復(fù)制機(jī)制研究（JQ2019C005），2019.07-2022.07，50萬元，主持。
黑龍江省“頭雁計(jì)劃”項(xiàng)目：獸醫(yī)病毒學(xué)創(chuàng)新研究頭雁團(tuán)隊(duì)，2019.01-2023.12，4000萬，學(xué)術(shù)骨干。
國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目：動(dòng)物流感病毒遺傳變異與致病機(jī)理研究（2016YFD0500200），2016.07-2021.06，4200萬元，參加。
國(guó)家自然科學(xué)基金創(chuàng)新研究群體項(xiàng)目：動(dòng)物流感病毒的進(jìn)化及其與宿主互作機(jī)制（31521005），2016.01-2021.12，1200萬元，學(xué)術(shù)骨干。
國(guó)家自然科學(xué)基金優(yōu)秀青年科學(xué)基金：流感病毒感染與變異（31422054），2015.01-2017.12，100萬元，主持。
國(guó)家自然科學(xué)基金面上項(xiàng)目：流感病毒M2 蛋白與宿主蛋白的相互作用及其分子機(jī)制研究（31472215），2015.01-2018.12，79萬元，主持。
中央級(jí)公益性科研院所基本科研業(yè)務(wù)費(fèi)專項(xiàng)：WNT-β-Catenin信號(hào)通路對(duì)流感病毒復(fù)制的調(diào)控機(jī)制研究（0302013016），2013.01-2014.12，110萬元，主持。
6、代表論文與著作
Guangwen Wang#, Yuhui Zhao#, Yuan Zhou#, Li Jiang, Libin Liang, Fandi Kong, Ya Yan, Xuyuan Wang, Yihan Wang, Xia Wen, Xianying Zeng, Guobin Tian, Guohua Deng, Jianzhong Shi, Liling Liu, Hualan Chen*, Chengjun Li*. PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence. PLoS Pathog. 2022 Apr 4;18(4):e1010446.
Yuhui Zhao#, Xia Wen#, Qibing Li, Li Jiang, Guangwen Wang, Libin Liang, Xiurong Wang, Hualan Chen*, Chengjun Li*. Generation and application of two monoclonal antibodies targeting conserved linear epitopes in the NP protein of influenza A virus. J Integr Agric. 2022 Jul; 21(7):2095–2105.
Wenjun Shi, Li Jiang, Miaomiao Ye, Bo Wang, Yu Chang, Zhibo Shan, Xuyuan Wang, Yuzhen Hu, Hualan Chen*, Chengjun Li*. A Single Amino Acid Residue R144 of SNX16 Affects Its Ability to Inhibit the Replication of Influenza A Virus. Viruses. 2022 Apr 15;14(4):825.
Jiaqi Cui, Pengfei Cui, Jianzhong Shi, Weifeng Fan, Xin Xing, Wenli Gu, Yuancheng Zhang, Yaping Zhang, Xianying Zeng, Yongping Jiang, Pucheng Chen, Huanliang Yang, Yan Chen, Jinxiong Liu, Liling Liu, Guobin Tian, Yixin Lu, Hualan Chen, Chengjun Li*, Guohua Deng*. Continued evolution of H6 avian influenza viruses isolated from farms in China between 2014 and 2018. Transbound Emerg Dis. 2021 Jun 30;doi: 10.1111/tbed.14212.
Junping Li#, Libin Liang#, Li Jiang#, Qian Wang, Xia Wen, Yuhui Zhao, Pengfei Cui, Yaping Zhang, Guangwen Wang, Qibing Li, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Yongping Jiang, Liling Liu, Hualan Chen*, Chengjun Li*. Viral RNA-binding ability conferred by SUMOylation at PB1 K612 of influenza A virus is essential for viral pathogenesis and transmission. PLoS Pathog. 2021 Feb 11;17(2):e1009336.
Nan Sun#, Li Jiang#, Miaomiao Ye, Yihan Wang, Guangwen Wang, Xiaopeng Wan, Yuhui Zhao, Xia Wen, Libin Liang, Shujie Ma, Liling Liu, Zhigao Bu, Hualan Chen*, Chengjun Li*. TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2. Protein Cell. 2020 Dec;11(12):894-914.
Chengjun Li, Hualan Chen*. H7N9 Influenza Virus in China. Cold Spring Harb Perspect Med. 2021 Aug 2;11(8):a038349.
Guangwen Wang, Li Jiang, Jinliang Wang, Jie Zhang, Fandi Kong, Qibing Li, Ya Yan, Shanyu Huang, Yuhui Zhao, Libin Liang, Junping Li, Nan Sun, Yuzhen Hu, Wenjun Shi, Guohua Deng, Pucheng Chen, Liling Liu, Xianying Zeng, Guobin Tian, Zhigao Bu, Hualan Chen, Chengjun Li*. The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry. J Virol. 2020 Jan 6;94(2):e01707-19.
Libin Liang#, Li Jiang#, Junping Li, Qingqing Zhao, Jinguang Wang, Xijun He, Shanyu Huang, Qian Wang, Yuhui Zhao, Guangwen Wang, Nan Sun, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Yongping Jiang, Liling Liu, Jinxiong Liu, Pucheng Chen, Zhigao Bu, Yoshihiro Kawaoka*, Hualan Chen*, Chengjun Li*. Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals. mBio. 2019 Jun 18;10(3):e01162-19.
Weiyu Luo#, Jie Zhang#, Libin Liang, Guangwen Wang, Qibing Li, Pengyang Zhu, Yuan Zhou, Junping Li, Yuhui Zhao, Nan Sun, Shanyu Huang, Chenchen Zhou, Yu Chang, Pengfei Cui, Pucheng Chen, Yongping Jiang, Guohua Deng, Zhigao Bu, Chengjun Li*, Li Jiang*, Hualan Chen*. Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication. PLoS Pathog. 2018 Jan 19;14(1):e1006851.
Guangwen Wang, Jie Zhang, Fandi Kong, Qibing Li, Jinliang Wang, Shujie Ma, Yuhui Zhao, Libin Liang, Junping Li, Nan Sun, Lizheng Guan, Yuan Zhou, Chenchen Zhou, Shanyu Huang, Zhigao Bu, Li Jiang, Hualan Chen*, Chengjun Li*. Generation and application of replication-competent Venus-expressing H5N1, H7N9, and H9N2 influenza A viruses. Sci Bull. 2018 Feb 15;63(3):176-186.
Pengyang Zhu, Libin Liang, Xinyuan Shao, Weiyu Luo, Shuitao Jiang, Qingqing Zhao, Nan Sun, Yuhui Zhao, Junping Li, Jinguang Wang, Yuan Zhou, Jie Zhang, Guangwen Wang, Li Jiang, Hualan Chen*, Chengjun Li*. Host cellular protein TRAPPC6A△ interacts with influenza A virus M2 protein and regulates viral propagation by modulating M2 trafficking. J Virol. 2016 Dec 16;91(1):e01757-16.
Chengjun Li#, Masato Hatta#, David F Burke#, Jihui Ping#, Ying Zhang#, Makoto Ozawa, Andrew S Taft, Subash C Das, Anthony P Hanson, Jiasheng Song, Masaki Imai, Peter R Wilker, Tokiko Watanabe, Shinji Watanabe, Mutsumi Ito, Kiyoko Iwatsuki-Horimoto, Colin A Russell, Sarah L James, Eugene Skepner, Eileen A Maher, Gabriele Neumann, Alexander I Klimov, Anne Kelso, John McCauley, Dayan Wang, Yuelong Shu, Takato Odagiri, Masato Tashiro, Xiyan Xu, David E Wentworth, Jacqueline M Katz, Nancy J Cox, Derek J Smith*, Yoshihiro Kawaoka*. Selection of antigenically advanced variants of seasonal influenza viruses. Nat Microbiol. 2016 May 23;1(6):16058.
Xiurong Wang#, Linlin Gu#, Jianzhong Shi, Haifeng Xu, Ying Zhang, Xianying Zeng, Guohua Deng, Chengjun Li*, Hualan Chen*. Development of a real-time RT-PCR method for the detection of newly emerged highly pathogenic H7N9 influenza viruses. J Integr Agric. 2017 Sep; 16(9):2055–2061.
Libin Liang#, Guohua Deng#, Jianzhong Shi, Shuai Wang, Qianyi Zhang, Huihui Kong, Chunyang Gu, Yuntao Guan, Yasuo Suzuki, Yanbing Li, Yongping Jiang, Guobin Tian, Liling Liu, Chengjun Li*, Hualan Chen*. Genetics, Receptor Binding, Replication, and Mammalian Transmission of H4 Avian Influenza Viruses Isolated from Live Poultry Markets in China. J Virol. 2015 Nov 18;90(3):1455-1469.
Chengjun Li, Hualan Chen*. Enhancement of influenza virus transmission by gene reassortment. Curr Top Microbiol Immunol. 2014;385:185-204.
Chengjun Li, Zhigao Bu, Hualan Chen*. Avian influenza vaccines against H5N1 'bird flu'. Trends Biotechnol. 2014 Mar;32(3):147-156.
Guohua Deng#, Dan Tan#, Jianzhong Shi, Pengfei Cui, Yongping Jiang, Liling Liu, Guobin Tian, Yoshihiro Kawaoka, Chengjun Li*, Hualan Chen*. Complex reassortment of multiple subtypes of avian influenza viruses in domestic ducks at the Dongting Lake Region of China. J Virol. 2013 Sep;87(17):9452-9462.
Jianzhong Shi#, Guohua Deng#, Peihong Liu, Jinping Zhou, Lizheng Guan, Wenhui Li, Xuyong Li, Jing Guo, Guojun Wang, Jun Fan, Jinliang Wang, Yuanyuan Li, Yongping Jiang, Liling Liu, Guobin Tian, Chengjun Li*, Hualan Chen*. Isolation and characterization of H7N9 viruses from live poultry markets—Implication of the source of current H7N9 infection in humans. Chin Sci Bull. 2013 Apr;58:1857-1863.
Chengjun Li#, Armand Bankhead 3rd#, Amie J Eisfeld, Yasuko Hatta, Sophia Jeng, Jean H Chang, Lauri D Aicher, Sean Proll, Amy L Ellis, G Lynn Law, Katrina M Waters, Gabriele Neumann, Michael G Katze*, Shannon McWeeney*, Yoshihiro Kawaoka*. Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus. J Virol. 2011 Nov;85(21):10955-10967.
Chengjun Li#, Masato Hatta#, Chairul A Nidom, Yukiko Muramoto, Shinji Watanabe, Gabriele Neumann, Yoshihiro Kawaoka*. Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4687-4692.
Chengjun Li, Masato Hatta, Shinji Watanabe, Gabriele Neumann, Yoshihiro Kawaoka*. Compatibility among polymerase subunit proteins is a restricting factor in the reassortment between equine H7N7 and human H3N2 viruses. J Virol. 2008 Dec;82(23):11880-11888.
Chengjun Li, Jihui Ping, Bo Jing, Guohua Deng, Yongping Jiang, Yanbing Li, Guobin Tian, Kangzhen Yu, Zhigao Bu, Hualan Chen*. H5N1 influenza marker vaccine for serological differentiation between vaccinated and infected chickens. Biochem Biophys Res Commun. 2008 Jul 25;372(2):293-297.
Yanbing Li#, Chengjun Li#, Liling Liu, Hongwei Wang, Chuanbin Wang, Guobing Tian, Robert G Webster, Kangzhen Yu, Hualan Chen*. Characterization of an avian influenza virus of subtype H7N2 isolated from chickens in northern China. Virus Genes. 2006 Aug;33(1):117-122.
Chengjun Li, Kangzhen Yu, Guobin Tian, Dandan Yu, Liling Liu, Bo Jing, Jihui Ping, Hualan Chen*. Evolution of H9N2 influenza viruses from domestic poultry in Mainland China. Virology. 2005 Sep 15;340(1):70-83.
《禽流感》，中國(guó)農(nóng)業(yè)出版社，2015年，副主編。
7、獲得獎(jiǎng)勵(lì)
H5N1亞型禽流感重組禽痘病毒活載體疫苗研究與應(yīng)用，黑龍江省科學(xué)技術(shù)進(jìn)步一等獎(jiǎng)，第七名，2008年。
動(dòng)物流感病毒引起人流感大流行的潛力及其遺傳機(jī)制，中國(guó)農(nóng)業(yè)科學(xué)院杰出科技創(chuàng)新獎(jiǎng)，第五名，2015年。
重組禽流感病毒（H5+H7）滅活疫苗的創(chuàng)制及應(yīng)用，黑龍江省科學(xué)技術(shù)進(jìn)步一等獎(jiǎng)，第六名，2021年。
8、專利和標(biāo)準(zhǔn)
李呈軍，陳化蘭，姜麗，曾顯營(yíng)，施建忠，梁立濱，田國(guó)彬. 流感病毒PB1蛋白抗原表位多肽及其用途. 專利授權(quán)號(hào)：ZL202011328413.4，中國(guó)，2021。
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