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1、個人簡歷

孟凡丹，女，博士，研究員，碩士/博士研究生導(dǎo)師。中國農(nóng)業(yè)科學(xué)院“青年英才計劃”引進工程院級入選者。主要研究方向：呼吸道病原體感染呼吸系統(tǒng)分子機制研究以及呼吸道病原體混合感染協(xié)同致病機制相關(guān)研究。主持黑龍江省自然科學(xué)基金優(yōu)秀青年項目1項，國家自然科學(xué)基金青年項目1項。以第一或通訊作者在Journal of Virology、Cellular Microbiology和Infection and Immunity等國際著名SCI期刊上發(fā)表論文11篇。指導(dǎo)在讀碩士研究生1名、在讀博士研究生3名。

2、聯(lián)系方式

（1）研究方向：病原組織嗜性、混合感染協(xié)同致病機制研究

（2）電話：0451-51051768

（3）郵箱：mengfandan@caas.cn

（4）通訊地址：黑龍江省哈爾濱市香坊區(qū)哈平路678號，150069

3、教育經(jīng)歷 

2016.04 - 2019.04  德國漢諾威獸醫(yī)大學(xué)，病毒學(xué)，DVM

2011.10 - 2015.10  德國漢諾威獸醫(yī)大學(xué)，病毒學(xué)，PhD

2008.09 - 2011.06  東北農(nóng)業(yè)大學(xué)，預(yù)防獸醫(yī)學(xué)，碩士

2003.09 - 2008.06  東北農(nóng)業(yè)大學(xué)，動物醫(yī)學(xué)，學(xué)士

4、工作經(jīng)歷

2022.02 - 至今 中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所，研究員

2018.07 - 2022.02 中國農(nóng)科院哈爾濱獸醫(yī)研究所  

2015.10 - 2017.09  德國漢諾威獸醫(yī)大學(xué)，博士后

5、主持或參與科研項目

1. 黑龍江省自然科學(xué)基金優(yōu)秀青年項目：高致病性PRRSV引起豬肺組織損傷分子機制的研究（YQ2019C030，2019.07-2022.07），10萬元

2. 國家自然科學(xué)基金青年科學(xué)基金項目：塞內(nèi)卡谷病毒經(jīng)豬呼吸道上皮細胞感染的入侵機制研究（32002249, 2021.01-2023.12），24萬元

6、代表論文與著作

1. Yang, Y.L*., Meng, F*., Qin, P., Herrler, G., Huang, Y.W., Tang, Y.D., 2020. Trypsin promotes porcine deltacoronavirus mediating cell-to-cell fusion in a cell type-dependent manner. Emerging microbes & infections 9, 457-468. 

2. Meng F, Tong J, V?tsch D, Peng J-Y, Cai X, Willenborg M, Herrler G, Wu N-H, Valentin-Weigand P, 2019. Viral co-infection replaces effects of suilysin on adherence and invasion of Streptococcus suis into respiratory epithelial cells grown under air-liquid interface conditions. Infection and immunity.doi:10.1128/IAI.00350-19.

3. Tong J, Fu Y, Wu N-H, Rohde M, Meng F*, Valentin‐Weigand P*, Herrler G*, 2018. Sialic acid-dependent interaction of group B streptococci with influenza virus-infected cells reveals a novel adherence and invasion mechanism. Cellular Microbiology. DOI:10.1111/cmi.12818.

4. Yang W, Punyadarsaniya D, Lambertz RL, Lee DC, Liang CH, H?per D, Leist SR, Hernández-Cáceres A, Stech J, Beer M, Wu CY, Wong CH, Schughart K, Meng F*, Herrler G*, 2017. Mutations during the adaptation of H9N2 avian influenza virus to the respiratory epithelium of pigs enhance the sialic acid binding activity and the virulence in mice. J Virol. JVI.02125-16. doi: 10.1128/JVI.02125-16.

5. Yang, Wei; L.O. Lambertzb, Ruth; Punyadarsaniyac, Darsaniya; R. Leist, Sarah; Stech, Jürgen; Schughart, Klaus; Herrler, Georg; Wu, Nai-Huei; Meng, F, 2017. Increased virulence of a PB2/HA mutant of an avian H9N2 influenza strain after three passages in porcine differentiated airway epithelial cells, Veterinary Microbiology, 10.16, 211: 129-134.

6. Wu NH, Yang W, Beineke A, Dijkman R, Matrosovich M, Baumg?rtner W, Thiel V, Valentin-Weigand P, Meng F*, Herrler G*, 2016. The differentiated airway epithelium infected by influenza viruses maintains the barrier function despite a dramatic loss of ciliated cells. Scientific reports. 6:39668. doi: 10.1038/srep39668.

7. Meng F, Wu NH, Seitz M, Herrler G, Valentin-Weigand P, 2016. Efficient suilysin-mediated invasion and apoptosis in porcine respiratory epithelial cells after streptococcal infection under air-liquid interface conditions. Scientific reports. 6, 26748.

8. Meng F, Wu NH, Nerlich A, Herrler G, Valentin-Weigand P, Seitz M. 2015. Dynamic viral-bacterial interactions in a porcine precision-cut lung slice co-infection model: swine influenza virus paves the way for Streptococcus suis infection in a two-step process. Infection and immunity. 83, 2806-2815.

9. Meng F, Suo S, Zarlenga DS, Cong Y, Ma X, Zhao Q, Ren X. 2014. A phage-displayed peptide recognizing porcine aminopeptidase N is a potent small molecule inhibitor of PEDV entry. Virology. 456-457:20-7. doi: 10.1016/j.virol.2014.01.010.

10. Meng F, Punyadarsaniya D, Uhlenbruck S, Hennig-Pauka I, Schwegmann-Wessels C, Ren X, Dürrwald R, Herrler G. 2013. Replication characteristics of swine influenza viruses in precision-cut lung slices reflect the virulence properties of the viruses. Vet Res. 13;44:110. doi: 10.1186/1297-9716-44-110.

11. Meng F, Ren Y, Suo S, Sun X, Li X, Li P, Yang W, Li G, Li L, Schwegmann-Wessels C, Herrler G, Ren X. 2013. Evaluation on the efficacy and immunogenicity of recombinant DNA plasmids expressing spike genes from porcine transmissible gastroenteritis virus and porcine epidemic diarrhea virus. PLoS One. 8(3):e57468. doi: 10.1371/journal.pone.0057468. Epub 2013 Mar 19.