走進(jìn)哈獸研
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科研進(jìn)展
科研成果
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1、個(gè)人簡歷
蔡雪輝，研究員，博士生導(dǎo)師，團(tuán)隊(duì)資深首席科學(xué)家。國務(wù)院特貼專家；國家“有突出貢獻(xiàn)中青年科學(xué)家”；黑龍江省領(lǐng)軍人才。主要集中于豬重要疫病的病原流行病學(xué)研究，側(cè)重于PRRS、PRV的分子流行病學(xué)研究、病原學(xué)和分子致病機(jī)制的研究。作為第1、2發(fā)明人獲得國家發(fā)明專利5項(xiàng)，獲新獸藥注冊(cè)證書2個(gè)。以第一完成人獲得國家科技進(jìn)步2等獎(jiǎng)1項(xiàng)、黑龍江省科技進(jìn)步一等獎(jiǎng)2項(xiàng)、神農(nóng)中華農(nóng)業(yè)科技獎(jiǎng)一、二等獎(jiǎng)各1項(xiàng)。發(fā)表SCI論文60余篇。
2、聯(lián)系方式
（1）研究方向：動(dòng)物病毒學(xué)及分子免疫學(xué)
（2）電話：0451-51051766
（3）郵箱：caixuehui@caas.cn
（4）通訊地址：黑龍江省哈爾濱市香坊區(qū)哈平路678號(hào)，150069
3、教育經(jīng)歷
2007.09-2012.12 吉林大學(xué)，動(dòng)物醫(yī)學(xué)院，獲博士學(xué)位，預(yù)防獸醫(yī)學(xué)
1999.09-2003.01 東北農(nóng)業(yè)大學(xué)，動(dòng)物醫(yī)學(xué)院，獲碩士學(xué)位，預(yù)防獸醫(yī)學(xué)
1986.09-1990.07 東北農(nóng)業(yè)大學(xué)，動(dòng)物醫(yī)學(xué)院，獲學(xué)士學(xué)位，獸醫(yī)公共衛(wèi)生
4、工作經(jīng)歷
2022.03-至今 豬藍(lán)耳病與偽狂犬病研究創(chuàng)新團(tuán)隊(duì)資深首席科學(xué)家
2013.06-2022.03 豬免疫抑制病研究創(chuàng)新團(tuán)隊(duì)首席科學(xué)家
2014.09-2016.06 哈爾濱獸醫(yī)研究所，動(dòng)物疫病診斷中心主任
2010.04-2014.09 哈爾濱獸醫(yī)研究所，動(dòng)物疫病診斷中心副主任
2009.01-2013.06 哈爾濱獸醫(yī)研究所豬病研究室研究組負(fù)責(zé)人，研究員
2001.12-2009.01 哈爾濱獸醫(yī)研究所豬病研究室研究組負(fù)責(zé)人，副研究員
1996.12-2001.12 哈爾濱獸醫(yī)研究所動(dòng)物疫病防制室，助理研究員
1993.05-1996.12 哈爾濱獸醫(yī)研究所禽病研究室，研究實(shí)習(xí)員
1990.07-1993.05 黑龍江省第一生物制品廠，見習(xí)獸醫(yī)師
5、承擔(dān)項(xiàng)目
“十二五”國家科技支撐計(jì)劃：新型動(dòng)物藥劑創(chuàng)制與產(chǎn)業(yè)化關(guān)鍵技術(shù)研究，（2015BAD11B02，2015.04-2019.12），630萬元.
6、代表論文與著作
[1] Wang S, Gao M, An T, Liu Y, Jin J, Wang G, Jiang C, Tu Y, Hu S, Li J, Wang J, Zhou D*, Cai X*. Genetic diversity and virulence of novel sequence types of Streptococcus suis from diseased and healthy pigs in China. Front Microbiol. 2015;6:173.
[2] Wang G, Yu Y, Tu Y, Tong J, Liu Y, Zhang C, Chang Y, Wang S, Jiang C, Zhou EM*, Cai X*. Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infection Induced Apoptosis and Autophagy in Thymi of Infected Piglets. PLoS One. 2015;10:e0128292.
[3] Wang G, Yu Y, Tu Y, Li Y, Tong J, Zhang C, Liu Y, Li A, Jiang C, Wang S, Tao Y, Cai X*. Characterizing the thymic lesions in piglets infected with attenuated strains of highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol. 2015. 168:258-61.
[4] Jiang C, An T, Wang S, Wang G, Si W, Tu Y, Liu Y, Wu J, Liu S*, Cai X*. Role of the ehxA gene from Escherichia coli serotype O82 in hemolysis, biofilm formation, and in vivo virulence. Can J Microbiol. 2015;61:335-41.
[5] Li Z, Wang G, Wang Y, Zhang C, Huang B, Li Q, Li L, Xue B, Ding P, Cai X*, Wang C*, Zhou EM*. Immune responses of pigs immunized with a recombinant porcine reproductive and respiratory syndrome virus expressing porcine GM-CSF. Vet Immunol Immunopathol. 2015;168:40-8.
[6] Yu Y, Wang G, Li Q, Du Y, Du T, Mu Y, Xiao S, Zhao Q, Wang C, Sun Y, Xu X, Zhang G, Hsu WH, Cai X*, Zhou EM*. Single-chain anti-idiotypic antibody retains its specificity to porcine reproductive and respiratory syndrome virus GP5. Immunol Lett. 2015;163:8-13.
[7] Tu YB#*, Wang G#, Wang YQ, Chen WY, Zhang L, Liu YG, Jiang CG, Wang SJ, Bu ZG, Cai XH*. Extracellular expression and antiviral activity of a bovine interferon-alpha through codon optimization in Pichia pastoris. Microbiol Res. 2016, 191: 12-18.
[8] Wang G#, Yu Y#, Zhang C#, Tu YB, Tong J, Liu YG, Chang YF, Jiang CG, Wang SJ, Zhou E-M*, Cai XH*. Immune responses to modified live virus vaccines developed from classical or highly pathogenic PRRSV following challenge with a highly pathogenic PRRSV strain. Dev Comp Immunol. 2016, 62: 1-7. doi: 10.1016/j.dci.2016.04.019.
[9] Dong JG#, Wang G#, Liu YG, Shi WD, Wu JN, Wen HQ, Wang SJ, Tian ZJ, Cai XH*. Quantitative estimation of the replication kinetics of genotype 2 PRRSV strains with different levels of virulence in vitro. J Virol Methods. 2016, 234: 87-9.
[10] Wang G#, Li L#,Yu Y, Tu YB, Tong J, Zhang C, Liu YG, Li YM , Han ZF, Jiang CG, Wang SJ, Zhou E-M, He XJ*, Cai XH*. Highly pathogenic porcine reproductive and respiratory syndrome virus infection and induction of apoptosis in bone marrow cells of infected piglets. J Gen Virol. 2016, 97: 1356-1361.
[11] Tang YD, Liu JT, Wang TY, An TQ, Sun MX, Wang SJ, Fang QQ, Hou LL, Tian ZJ, Cai XH. Live attenuated pseudorabies virus developed using the CRISPR/Cas9 system. Virus Res 2016, 225:33-39.
[12] Tang YD#, Fang QQ#, Liu JT, Wang TY, Wang Y, Tao Y, Liu YG*, Cai XH*. Open reading frames 1a and 1b of the porcine reproductive and respiratory syndrome virus (PRRSV) collaboratively initiate viral minus-strand RNA synthesis. Biochem Biophys Res Commun. 2016, doi: 10.1016/j.bbrc.2016. 06.161
[13] Tang YD#, Liu JT#, Fang QQ#, Wang TY#, Sun MX, An TQ, Tian ZJ, Cai XH*. (2016b). Recombinant Pseudorabies Virus (PRV) Expressing Firefly Luciferase Effectively Screened for CRISPR/Cas9 Single Guide RNAs and Antiviral Compounds. Viruses. 2016, 8(4).
[14] Mingxia Sun, Linlin Hou, Yan-dong Tang, Yonggang Liu, Shujie Wang, Jingfei Wang, Nan Shen, Tongqing An, Zhijun Tian & Xuehui Cai, Pseudorabies virus infection inhibits autophagy in permissive cells in vitro, Sci Rep. 2017 Jan 6;7:39964
[15]Yan-Dong Tang, Ji-Ting Liu, Tong-Yun Wang, Ming-Xia Sun, Zhi-Jun Tian, Xue-Hui Cai* Comparison of Pathogenicity-Related Genes in the Current Pseudorabies Virus Outbreak in China. 2017, Sci Rep. 2017 Aug 10;7(1):7783. doi: 10.1038/s41598-017-08269-3.
[16] Zhang HL, Zhang WL, Xiang LR, Leng CL, Tian ZJ, Tang YD, Cai XH. 2018. Emergence of novel porcine reproductive and respiratory syndrome viruses (ORF5 RFLP 1-7-4 viruses) in China. Vet Microbiol 222:105-108.
[17] Zhang HL, Tang YD, Liu CX, Xiang LR, Zhang WL, Leng CL, Wang Q, An TQ, Peng JM, Tian ZJ, Cai XH. 2018. Adaptions of field PRRSVs in Marc-145 cells were determined by variations in the minor envelope proteins GP2a-GP3. Vet Microbiol 222:46-54.
[18]Tang YD, Guo JC, Wang TY, Zhao K, Liu JT, Gao JC, Tian ZJ, An TQ, Cai XH. 2018. CRISPR/Cas9-mediated 2-sgRNA cleavage facilitates pseudorabies virus editing. FASEB J 32:4293-4301.
[19] Wang HM, Liu TX, Wang TY, Wang G, Liu YG, Liu SG, Tang YD, Cai XH. 2018. Isobavachalcone inhibits post-entry stages of the porcine reproductive and respiratory syndrome virus life cycle. Arch Virol 163:1263-1270.
[20]Wang TY, Liu YG, Li L, Wang G, Wang HM, Zhang HL, Zhao SF, Gao JC, An TQ, Tian ZJ, Tang YD, Cai XH. 2018. Porcine alveolar macrophage CD163 abundance is a pivotal switch for porcine reproductive and respiratory syndrome virus infection. Oncotarget 9:12174-12185.
[21] Wang TY, Fang QQ, Cong F, Liu YG, Wang HM, Zhang HL, Tian ZJ, Tang YD, Cai XH. 2019. The Nsp12-coding region of type
[22]PRRSV is required for viral subgenomic mRNA synthesis. Emerg Microbes Infect 8:1501-1510.
[23]Wang TY, Yang YL, Feng C, Sun MX, Peng JM, Tian ZJ, Tang YD, Cai XH. 2020. Pseudorabies Virus UL24 Abrogates Tumor Necrosis Factor Alpha-Induced NF-kappaB Activation by Degrading P65. Viruses 12.
[24]Wang SJ, Lyc C, Duan GX, Meng FD, Yang YB, Yu Y, He XJ, Wang ZZ, Gottschalk M, Li GW, Cai XH*, Wang G*.Streptococcus suis Serotype 2 Infection Causes Host Immunomodulation Through Induction of Thymic Atrophy. Infect Immun. 2020. Accept.
7、專利和標(biāo)準(zhǔn)
1）“豬繁殖與呼吸綜合征病毒弱毒疫苗株及應(yīng)用”。蔡雪輝，郭寶清，王洪峰，柴文君。發(fā)明專利，2009年，ZL 200710001253.0。
2）豬圓環(huán)病毒II型衣殼蛋白基因、表達(dá)載體的構(gòu)建及其蛋白高效表達(dá)的方法。蔡雪輝，涂亞斌，武嘉男。發(fā)明專利，2013年，ZL201210128807.4。
3）豬鏈球SBP_bac_5基因缺失株及其構(gòu)建方法和應(yīng)用。蔡雪輝，王淑杰，劉永剛。發(fā)明專利，2017年，ZL201510058245.4。
4）實(shí)驗(yàn)動(dòng)物麻醉用注射器。蔡雪輝，王淑杰。實(shí)用新型專利，2015年，ZL201420531444.3。
5）小動(dòng)物手術(shù)用手術(shù)臺(tái)。蔡雪輝，王淑杰。實(shí)用新型專利，2015年，ZL201520087430.1。
8、獲得獎(jiǎng)勵(lì)
1）2006年和2009年獲得省科學(xué)技術(shù)一等獎(jiǎng)2項(xiàng)，排名第一；
2）2009年獲神農(nóng)中華農(nóng)業(yè)科技獎(jiǎng)二等獎(jiǎng)1項(xiàng)，排名第一；
3）2010年獲國家科技進(jìn)步2等獎(jiǎng)1項(xiàng)，排名第一；
4）2013年獲“國務(wù)院特貼專家”稱號(hào)；
5）2014年獲“有突出貢獻(xiàn)中青年科學(xué)家”稱號(hào)；
6）2015年獲“黑龍江省科技領(lǐng)軍人才梯隊(duì)帶頭人”稱號(hào)；
7）2015年獲“中華農(nóng)業(yè)科技獎(jiǎng)-優(yōu)秀創(chuàng)新團(tuán)隊(duì)獎(jiǎng)”排名第一；
8）2016年獲“第二屆哈爾濱科技創(chuàng)新團(tuán)隊(duì)獎(jiǎng)”排名第一；
9）2017年獲“黑龍江省勞動(dòng)模范”稱號(hào)。
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